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Ginseng appears to protect brain

MHRA reviews ginseng study

Ginseng shows memory-boosting potential


03/06/2005 - Components of the herbal ginseng protect the brain against the
kind of deterioration caused by degenerative diseases like Huntingdon's,
suggests a new study on rats.

Ginseng is most commonly used in the West to boost energy (increasingly in
energy drinks) and to support the immune system. But there is already some
evidence of its benefits to the brain. A small Chinese trial reported two
years ago found that a ginseng compound improved memory scores of people
suffering from stroke-induced dementia.
In the new study, a team from Baylor College of Medicine in Houston, US,
investigated whether a purified form of ginseng, in which some of the
herb's active chemicals had been concentrated, could protect rats from the
effects of a toxin that caused severely impaired movement and loss of neurons.

The chemical used was designed to mimic the degenerative process seen in
Huntington's disease, but the rat model could also be relevant to other
degenerative diseases like Parkinson's.

The rats received either the purified ginseng extract, rich in the
ginsenosides known as Rb(1), Rb(3), or Rd, or a preparation from the whole
root of American ginseng. A third group were given a preparation of ground
leaves and stems, which contains greater levels of ginsenosides than ground
root.

The concentrated extract had the most benefit. It significantly reduced the
induced motor impairment and cell loss in the striatum, and it completely
prevented any mortality, write the researchers in this month's issue of the
Annals of Neurology (vol 57, pp642-648).

"A partial purification of whole ginseng to concentrate the neuroprotective
components may have utility as a neuroprotective agent," concluded the
researchers.

Rats given the preparation of ground leaves and stems gained some
protection - an improved behavioural score and less damage to the striatum.
But pretreatment with a preparation from the whole root of American ginseng
had no protective effects and even increased mortality.

This suggests that some components need to be taken out of the whole
ginseng root in order to isolate the useful ones and make it safe for
future trials in humans.

It is thought that certain ginsenosides may act as antioxidants against the
oxidative damage thought to contribute to conditions like Huntington's and
Parkinson's disease. The latter is thought to affect 1 per cent of people
over the age of 65 worldwide.

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