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Hi Merv, For what reason does your Neuro say your 'undermedicated'? I don't know your situation or history but compared to me I'd say you were overmedicated. I won't bore you with mydetails and ideas here, as most of it is in my emails in the PIENO archive which, now I'm back, I intend to consolidate and update and make available to the group. But just let me say this for now; based on my experience I have no confidence in Neuro's and GP's and I have no faith in the Pharmaceutical industry coming up with a cure because they are only interested in drugs to manage[supress] symptoms, of a given illness, for as long as possible, because of the $dollars. PWPers are a 'gold mine' for them. I was told I was under medicated in august 1999 and my Permax was increased to 3mg/day from 1mg/day. Three months later I started to have swollen feet/ankles/legs. My GP concluded that this was due to inactivity and in consultation with my Neuro prescribed Sinemet(size 62,5). So from September 2000 I was taking 3mg Permax and 3 (62,5) per day. There was no improvement in my mobility, the swelling got worse and I started having problems with sleep. My GP said I should increase the Sinemet; I refused. Here we are 5yrs later and I'm no worse, if anything alittle better, especially if I get a good nights sleep, and I'm only taking 2mg Permax and 2(62,50 Sinemet per day. I reduced the daily dose more than 18months ago. And I'm glad I did because I recently read that a Canadian leading Neuro has conclusive evidence that Permax causes serious damage to the heart, such that it should be withdrawn [he presented his paper in April 2004) and Permax is still being prescribed, neither my GP nor Neuro have contacted me to switch agonist!] I have only ever taken one other drug for a long period, Prothiadenn, an anti-depressant, 8/1988 to 1/1990. This is no longer prescribed as it had dangerous side-effects, like indducing Prkinsons! More later. Marco ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn