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I can't understand a word of this, Ray Dr. Chu's research focuses upon the roles of redox cell signaling and pathologic autophagy in neurodegeneration and Parkinson's disease. Molecular and biochemical studies in cell culture and mouse models are integrated with studies of diseased human brain tissues. A major focus is delineating why adaptive responses to oxidative and environmental neurotoxins fail. Laboratory members have shown that inappropriate regulation of extracellular signal regulated protein kinase (ERK) and autophagy may result in conversion of these cellular responses into detrimental pathways. Oxidative neurotoxins elicit decreased neuroprotective transcriptional factor activity accompanied by alterations in the subcellular trafficking of activated signaling proteins. Similar alterations in subcellular localization are observed in human neurodegenerative disease brain tissues. Current areas of interest include: 1) mechanisms and consequences of redox-activated ERK and CREB signaling, 2) regulation of autophagy and cell death, and 3) PINK1, a novel mitochondrial kinase implicated in familial Parkinson's disease. Presentation Title: Diversion of signaling pathways during oxidative Parkinsonian injury. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn