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Hi Lee, and glad you didn't die from the Tasmar like some did, Ray
----- Original Message -----
From: "Lee Wu" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Tuesday, November 15, 2005 8:19 PM
Subject: Re: Psychosis in Parkinsons


> Dear Catherine,
>  Not sure about the Sinemet causing psychotic episodes, for me it was the
> add on anti parkinsonian meds ie agonist drug Permax. When stopped my
> clarity of thought ability to concentrate etc returned although that's
> different to psychosis.
>   I can recall a rather ugly episode when I stopped Tasmar ( a COMT
> inhibitor) abruptly and was convinced of things that hadn't even happened
> so I'm guessing that was a psychotic episode. Maybe it was the agonist
> Permax but the pharmacy was unable to obtain Tasmar and this was day three
> of suddenly having none.
>  Hope this helps, a Neurologist told me that Sinemet is the gold standard
> drug and the other drugs (with my history) are not worth the risk of
> taking due to behavioural issues.
>                                 Lee
>
> Catherine Roberts <[log in to unmask]> wrote:
>  My mother has rather advanced Parkinson's and has been suffering quite
> serious psychotic delusions as a side effect (presumably) of the sinemet.
> Is
> anyone aware of any non-surgical treatment alternatives that would address
> the Parkinson's symptoms while minimizing the psychosis? I am aware of the
> role of dopamine in all of this, but she has been trying to find the right
> balance between the sinemet and the antipsychotic meds used to try and
> control the psychosis for a long time with only limited success. If there
> are any other treatment alternatives out there I would be grateful for any
> information you could pass on. Thanks very much.
>
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