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Well said, Carole Carole M. ----- Original Message ----- From: "Carole Hercun" <[log in to unmask]> To: <[log in to unmask]> Sent: Saturday, January 14, 2006 7:01 AM Subject: Re: mirapex and requip / Another Point of View > Because it works. For me. PD is a designer disease, and > what works for one of us may not for another. I write now > that I can no longer practice as a psychiatric nurse, and I > need to be mentally alert, creative, etc. > The Sinemet does that for me. I remember the first time I > took it. I could almost hear those dormant brain synapses > buzzing. I also take Mirapex as an adjunct med, and while > it helps, it leaves me foggy and forgetful. I am now > beginning to have some dyskenesia, which is a b---h, but I > am dealing with it because the drug enables me to write, > and walk. > A last thought-L-dopa has been around a very long time. We > know its side-effects, etc. As a nurse I saw many new meds > marketed as having no s/e's. Prozac is a good example. Then > a few years down the pike they are blaming it for > everything from suicides on down. > We have also seen good old reliable drugs turn out to be > toxic, i.e., Tylenol and liver damage. So, I think its > pretty much like life. You pick your poison, and you take > your chances... > Peace, > Carole Hercun > > --- m power <[log in to unmask]> wrote: > >> hi all, >> >> in what i am about to say, i am speaking in general >> terms - i do not mean to minimize anyone's experience of >> the side effect of obsessive behavior. >> >> In the study that came out in 2003, 1.5% of the people >> who were put on mirapex developed serious gambling >> addictions - that is "only slightly higher than the >> reported rate in the general population, which ranges >> from 0.3 to 1.3%." does anyone know if that is even >> statistically >> > significant?(http://www.abc.net.au/science/news/health/HealthRepublish_922460.htm) >> >> by contrast, 100% of early onset folks put on l-dopa >> will develop both dyskinesias and on/off fluctuations >> within 6 years (see Quinn, Young Onset Parkinson's >> Disease, 1987, Movement Disorders, Vol. 2, no.2, p. >> 73-91) and 75% of people put on l-dopa "will no longer >> have a smooth, stable and effective response" after five >> years of treatment - in other words, 75% overall will >> develop dyskinesias and on/off fluctuations within five >> years (see Fahn, Parkinson Disease, The Effect of >> Levodopa and the ELLDOPA trial, Archives of Neurology, >> 1999) >> >> i am curious - i do not experience on/off fluctuations >> or dyskinesias, having never taken l-dopa, because >> looking in from the outside, it looks like somewhere i >> would do everything i could to avoid going. and yet, >> people rarely talk about them (and they certainly don't >> get the press 1.5% gambling does, but of course that >> could be because these other statistics have been well >> known in the research community for at least 20 years) - >> are they just not as bad as i think they are? or are >> folks resigned to experiencing them because l-dopa is the >> only thing that works (or worked) for them? or do folks >> not know that the risk is so high until it is upon them? >> >> if anyone has any thoughts on the subject, i would love >> to hear them. i simply cannot understand how a drug that >> has such a gargantuan chance of leaving people with >> disabling side effects has been "the gold standard"' for >> about 40 years. >> >> mackenzie >> >> >> Beverly Forte <[log in to unmask]> wrote: I too stopped >> Mirapex because of some compulsive behaviors and my >> neurologist refuses to give me Requip. I had dbs brain >> surgery in Dec 2005. >> After stopping the mirapex i went into a deep depression >> which does not seem >> responsive to antidepressents. My energy is also >> extremely low. Obsessive >> behaviors now? Nope.. I am lucky to get out of bed every >> day. Has anyone had >> this experience and any suggestions? I have a doctor's >> app Jan 16th and hope >> to have my own suggestions. >> >> Thanks...for sharing. >> >> Bev in Tex >> >> ----- Original Message ----- >> From: "Automatic digest processor" >> >> To: "Recipients of PARKINSN digests" >> >> Sent: Thursday, January 12, 2006 11:32 PM >> Subject: PARKINSN Digest - 11 Jan 2006 to 12 Jan 2006 >> (#2006-18) >> >> > ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn >> >> >> >> >> --------------------------------- >> Yahoo! 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