Nick, I'm taking 50/200 mg Carbidopa/Levodopa ER (generic Sinemet) with 200 mg Comtan four times a day. If I have protein during the day, it tends to shorten the "up" time of the dose I'm on or delays the ramping up of the next dose I take. I have noticed that I have the most trouble when I choose my protein from the top of the food chain (beef, etc.)and less when I'm using vegetable protein like rice and beans. A PD dietician who contributes to this dialogue recommends half a gram of protein for every pound of body weight per day. In your note, you mentioned 2 1/2 Sinemet. Does the 2 1/2 represent the number of pills or the size of each? All the best to you both, Geo. Nick & Oanh <[log in to unmask]> Sent by: Parkinson's Information Exchange Network <[log in to unmask]> 01/23/06 02:12 AM Please respond to Parkinson's Information Exchange Network <[log in to unmask]> To [log in to unmask] cc Subject Sinemet & Comtan Is this unusual? My wife took 2 1/2 sinemet cr and 1 comtan at 11am. At 12:30pm she ate some fish and shrimp, rice and salad. At 3pm she took another 2 1/2 sinemet cr and 1 comtan. It never kicked in. I had her take another sinemet/comtan dose at 6pm. It didn't kick in by 7:10pm, so she took one more sinemet cr. It finally kicked in at 7:40pm. Any idea why it didn't kick in 2 times? Nick caregiver for Oanh, 14 yrs pd ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn