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I am participating in a double blind study at ohsu regarding interactions between mirapex and sinemet. These are my observations at one month into the study (which is about 2.5 month long one half I will have mirapex and then for the other I will be sans and I will need to stay at their research center for a couple of nights after each phase.). I was on mirapex .5 * 3 for about 2 yr prior to starting this study. I am sleeping through the night now which is one plus. I am spending less on lottery tickets (about $5 /wk as compared to $10) but this is probably because my car broke down and its more difficult to get to the store. This drug has been associated with other types of compulsive behavior than gambing though and my libido is definitely decreased. My off times are more pronounced and longer and the sinemet takes longer to work. This has decreased the total amount of physical activity I am able to do during the day. I am in general easier to get along with according to my wife. I have a lot less dyskinetic motion. If anyone is interested I wll post my observations a month into the next phase. \Randy Games to entertain your brain. http://www.stargraphics.com Star Graphics Corp 10943 S Forest Ridge Ln Oregon City, OR 97045 ----- Original Message ----- From: "m power" <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, February 17, 2006 7:48 AM Subject: Re: Gambling >i just spoke to the FDA - they did not release any such information - and >it is not on their website. rather, several researchers accessed the FDA >"Adverse Event Reporting System" (AERS) database and did an analysis. at >the end of the article, it says: > > The opinions expressed in this article are those of the authors and not > necessarily an official position of the Food and Drug Administration. > > The study also says that the first reports to the FDA regarding mirapex > came in 2003 (at least that is what i think it says - i will be > contacting either the FDA or the researchers to find out for sure - but if > so, one has to wonder if there were any reports before the first media > blitz which was, i think, in 2003 - must check on that, too) and these > stimulated more reports and this may have increased the "scores" for > mirapex. > > > rayilynlee <[log in to unmask]> wrote: > I keep seeing ads for Requip to treat RLS on TV and wonder why they don't > include the info that this is a PD agonist. Ray > ----- Original Message ----- > From: "M.Schild" > To: > > Sent: Thursday, February 16, 2006 12:09 AM > Subject: Gambling > > >> Parkinson's Drug May Cause Compulsive Gambling >> >> >> >> >> >> Parkinson's Drug May Cause Compulsive Gambling >> >> >> >> >> http://www.consumeraffairs.com/news04/2006/02/fda_parkinsons.html >> >> February 15, 2006 >> Medicine used to treat Parkinson's disease has an unusual side effect: >> compulsive gambling, according to the Food and Drug Administration. >> The agency said an analysis of adverse drug effects found that the >> strongest >> association with gambling was for Mirapex (pramipexole), which accounted >> for >> 39, or 58%, of reports of pathological gambling. Five other Parkinson's >> drugs >> also showed elevated risks. >> The results were drawn from an FDA database of more than 2.5 million >> adverse >> drug reports dating back to 1968. >> The latest results are consistent with earlier observations and add to >> evidence that Parkinson's drugs may lead to impulsive behavior as they >> make >> up for depleted dopamine, a brain chemical whose deficiency marks the >> disease. >> The findings appear in the February issue of the Archives of Neurology. >> An earlier article in the journal described 11 Parkinson's patients who >> developed pathological gambling after being treated with drugs for >> Parkinson's disease. >> A spokesman for Boehringer Ingelheim, the German company that makes >> Mirapex, >> said the company is working with Parkinson's disease experts "to >> investigate >> the relationship, if any" between Parkinson's drug therapy and compulsive >> behavior. >> >> >> February 15, 2006 >> Medicine used to treat Parkinson's disease has an unusual side effect: >> compulsive gambling, according to the Food and Drug Administration. >> The agency said an analysis of adverse drug effects found that the >> strongest >> association with gambling was for Mirapex (pramipexole), which accounted >> for >> 39, or 58%, of reports of pathological gambling. Five other Parkinson's >> drugs >> also showed elevated risks. >> The results were drawn from an FDA database of more than 2.5 million >> adverse >> drug reports dating back to 1968. >> The latest results are consistent with earlier observations and add to >> evidence that Parkinson's drugs may lead to impulsive behavior as they >> make >> up for depleted dopamine, a brain chemical whose deficiency marks the >> disease. >> The findings appear in the February issue of the Archives of Neurology. >> An earlier article in the journal described 11 Parkinson's patients who >> developed pathological gambling after being treated with drugs for >> Parkinson's disease. >> A spokesman for Boehringer Ingelheim, the German company that makes >> Mirapex, >> said the company is working with Parkinson's disease experts "to >> investigate >> the relationship, if any" between Parkinson's drug therapy and compulsive >> behavior. >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > > > > --------------------------------- > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > Relax. 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