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I keep seeing ads for Requip to treat RLS on TV and wonder why they don't include the info that this is a PD agonist. Ray ----- Original Message ----- From: "M.Schild" <[log in to unmask]> To: <[log in to unmask]> Sent: Thursday, February 16, 2006 12:09 AM Subject: Gambling > Parkinson's Drug May Cause Compulsive Gambling > > > > > > Parkinson's Drug May Cause Compulsive Gambling > > > > > http://www.consumeraffairs.com/news04/2006/02/fda_parkinsons.html > > February 15, 2006 > Medicine used to treat Parkinson's disease has an unusual side effect: > compulsive gambling, according to the Food and Drug Administration. > The agency said an analysis of adverse drug effects found that the > strongest > association with gambling was for Mirapex (pramipexole), which accounted > for > 39, or 58%, of reports of pathological gambling. Five other Parkinson's > drugs > also showed elevated risks. > The results were drawn from an FDA database of more than 2.5 million > adverse > drug reports dating back to 1968. > The latest results are consistent with earlier observations and add to > evidence that Parkinson's drugs may lead to impulsive behavior as they > make > up for depleted dopamine, a brain chemical whose deficiency marks the > disease. > The findings appear in the February issue of the Archives of Neurology. > An earlier article in the journal described 11 Parkinson's patients who > developed pathological gambling after being treated with drugs for > Parkinson's disease. > A spokesman for Boehringer Ingelheim, the German company that makes > Mirapex, > said the company is working with Parkinson's disease experts "to > investigate > the relationship, if any" between Parkinson's drug therapy and compulsive > behavior. > > > February 15, 2006 > Medicine used to treat Parkinson's disease has an unusual side effect: > compulsive gambling, according to the Food and Drug Administration. > The agency said an analysis of adverse drug effects found that the > strongest > association with gambling was for Mirapex (pramipexole), which accounted > for > 39, or 58%, of reports of pathological gambling. Five other Parkinson's > drugs > also showed elevated risks. > The results were drawn from an FDA database of more than 2.5 million > adverse > drug reports dating back to 1968. > The latest results are consistent with earlier observations and add to > evidence that Parkinson's drugs may lead to impulsive behavior as they > make > up for depleted dopamine, a brain chemical whose deficiency marks the > disease. > The findings appear in the February issue of the Archives of Neurology. > An earlier article in the journal described 11 Parkinson's patients who > developed pathological gambling after being treated with drugs for > Parkinson's disease. > A spokesman for Boehringer Ingelheim, the German company that makes > Mirapex, > said the company is working with Parkinson's disease experts "to > investigate > the relationship, if any" between Parkinson's drug therapy and compulsive > behavior. > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn