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Here is what it says in the "read me" file that accompanies the FDA's Adverse Event Reporting System database when one downloads a chunk of it: "For any given report, there is no certainty that a suspected drug caused the reaction. This is because physicians are encouraged to report suspected reactions; however, the event may have been related to the underlying disease being treated, or caused by some other drug being taken concurrently, or simply occurred by chance at that time. Accumulated reports cannot be used to calculate incidence (occurrence rates) or to estimate drug risk. Comparisons between drugs cannot be made from these data." must see whether i can submit a response to this article... rayilynlee <[log in to unmask]> wrote: I keep seeing ads for Requip to treat RLS on TV and wonder why they don't include the info that this is a PD agonist. Ray ----- Original Message ----- From: "M.Schild" To: Sent: Thursday, February 16, 2006 12:09 AM Subject: Gambling > Parkinson's Drug May Cause Compulsive Gambling > > > > > > Parkinson's Drug May Cause Compulsive Gambling > > > > > http://www.consumeraffairs.com/news04/2006/02/fda_parkinsons.html > > February 15, 2006 > Medicine used to treat Parkinson's disease has an unusual side effect: > compulsive gambling, according to the Food and Drug Administration. > The agency said an analysis of adverse drug effects found that the > strongest > association with gambling was for Mirapex (pramipexole), which accounted > for > 39, or 58%, of reports of pathological gambling. Five other Parkinson's > drugs > also showed elevated risks. > The results were drawn from an FDA database of more than 2.5 million > adverse > drug reports dating back to 1968. > The latest results are consistent with earlier observations and add to > evidence that Parkinson's drugs may lead to impulsive behavior as they > make > up for depleted dopamine, a brain chemical whose deficiency marks the > disease. > The findings appear in the February issue of the Archives of Neurology. > An earlier article in the journal described 11 Parkinson's patients who > developed pathological gambling after being treated with drugs for > Parkinson's disease. > A spokesman for Boehringer Ingelheim, the German company that makes > Mirapex, > said the company is working with Parkinson's disease experts "to > investigate > the relationship, if any" between Parkinson's drug therapy and compulsive > behavior. > > > February 15, 2006 > Medicine used to treat Parkinson's disease has an unusual side effect: > compulsive gambling, according to the Food and Drug Administration. > The agency said an analysis of adverse drug effects found that the > strongest > association with gambling was for Mirapex (pramipexole), which accounted > for > 39, or 58%, of reports of pathological gambling. Five other Parkinson's > drugs > also showed elevated risks. > The results were drawn from an FDA database of more than 2.5 million > adverse > drug reports dating back to 1968. > The latest results are consistent with earlier observations and add to > evidence that Parkinson's drugs may lead to impulsive behavior as they > make > up for depleted dopamine, a brain chemical whose deficiency marks the > disease. > The findings appear in the February issue of the Archives of Neurology. > An earlier article in the journal described 11 Parkinson's patients who > developed pathological gambling after being treated with drugs for > Parkinson's disease. > A spokesman for Boehringer Ingelheim, the German company that makes > Mirapex, > said the company is working with Parkinson's disease experts "to > investigate > the relationship, if any" between Parkinson's drug therapy and compulsive > behavior. > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn --------------------------------- ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn Relax. Yahoo! Mail virus scanning helps detect nasty viruses!