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From a subjective point of view mirapex exacerbates dyskenesia dramaticly. I am midway thru a study on this issue at ohsu in portland. Dyskinesia disappeared almost completely w/o the mirapex but of course there are some very positive benefits to mirapex also. I can amubulate! There is also a much better chance of winning the lottery. It will be interesting to see the published report at the end of the study. \Randy Games to entertain your brain. http://www.stargraphics.com Star Graphics Corp 10943 S Forest Ridge Ln Oregon City, OR 97045 ----- Original Message ----- From: "mackenzie" <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, March 10, 2006 9:02 PM Subject: tardive vs. levodopa induced dyskinesias > Antipsychotics and levodopa are the only compounds as > far as i know that are known to cause dyskinesia. > Antipsychotics, also called neuroleptics, cause what > are called tardive dyskinesias (TDs), and levodopa > causes the various types of levodopa-induced > dyskinesias (LIDs). > > The main difference between tardive and l-dopa induced > dyskinesias is that the former is "potentially" > irreversible (presumably the more developed they are > the less likely they are to go away even if treatment > is stopped) and the latter is not considered permanent > because they stop if treatment is stopped. > > But honestly - short of having DBS, does anyone ever > go off l-dopa? As long as one has no choice but to > remain on l-dopa, dyskinesias are, practically > speaking, permanent. So, from that perspective they > can be said to be comparable. > > i wanted to provide some sense of how disabling each > type dyskinesia is capable of becoming, and with what > frequency, but i could not find any studies/abstracts > comparing the two. > > However, there is one way in which the two are > quantifiably different - LIDs are a *much* bigger risk > than TDs - with, according to one study, the 7 year > risk of developing TDs being 35% (on an old > neuroleptic - there are newer ones that are less > likely to cause TDs), while according to another study > the 10 year risk is just 11.4% - vs. the 5-year risk > of developing LIDs being anywhere from 50-100%, > depending on one's age and which study one cites. > > And yet, in spite of a much bigger risk of LIDs, a > mere 47 words are devoted to dyskinesias in the > Sinemet labeling (in one section, one is instructed to > call one's physician if one starts experiencing > involuntary movements or nausea), whereas Navane, and > old neuroleptic, devotes 535 in three different > sections to TDs, including the first paragraph in the > "WARNING" section, and Zybrexa, a new neuroleptic, > devotes 365. > > i would like to know why that is. > > > __________________________________________________ > Do You Yahoo!? > Tired of spam? Yahoo! Mail has the best spam protection around > http://mail.yahoo.com > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn