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C. Brandta

H. Grunzeb

C. Normanna

J.Waldena

Departments of Psychiatry,

a University of Freiburg and

b University of Munich, Germany

Acetazolamide in the

Treatment of Acute Mania

A Case Report

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Key Words

Acetazolamide

Mania

Carbonic anhydrase inhibitor

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Abstract

Several antiepileptic drugs are also being used in affective disorders. There are some hints that also the carbonic anhydrase inhibitor acetazolamide might be useful in the treatment of bipolar affective disorder. We report a 39-yearold male patient with a history of bipolar affective disorder who presented with his second manic episode. Acetazolamide was added to a low dose of valproic acid and to perazine. A marked decrease of the BRMAS score was achieved. The implications of this case are discussed.

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