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Where were these published? Were they just abstracts? I was a subject in the second study and could describe by experience for the group when I have more time, if folks are interested. ----- Original Message ----- From: "M.Schild" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, May 10, 2006 10:38 AM Subject: patches > 1. Rotigotine transdermal system in a multicenter trial of patients with > advanced-stage Parkinson's disease as adjunctive therapy to levodopa > P LeWitt, P Nausieda, FL Chang, E Fazzini, D Truong, M Carpenter, K > Sommerville, B Boroojerdi, SP650 Study Group > S32.003, A184-185 > > Transdermal rotigotine can reduce off time without increasing troublesome > dyskinesias, according to this study. > > Three hundred fifty-one PD patients with at least 2.5 hours daily off time > were randomized to rotigotine 40 sq. cm, rotigotine 60 sq. cm, or placebo, > for 29 weeks. Three quarters of patients completed the trial. Mean daily off > time reduction was 2.7 hours. 2.1 hours, and 0.9 hours, respectively. There > was no increase in on time with troublesome dyskinesias. Redness and itching > at the application site, and edema, were greater in patients receiving > rotigotine. Discontinuations due to adverse events occurred in 16% of > patients receiving rotigotine, versus 8% of patients receiving placebo. > > Supported by Schwarz Pharma > > 2. Continuous dopaminergic stimulation with lisuride TTS (patch) in moderately > advanced Parkinsonian patients > T Dimitrova, W Bara-Jiminez, M Thomas, F Bibbiani, X Zhiang, T Chase > S23.004, A185 > > Treatment with transdermal lisuride reduces motor fluctuations, according to > this study. > > Twenty patients were randomized to transdermal lisuride or placebo for 16 > weeks. UPDRS motor scores improved by 5 pts in patients receiving lisuride, > versus 0 in those receiving placebo. Levodopa dose was reduced by 50% in > patients receiving lisuride without loss of motor benefit. Dyskinesia scores > did not change as a result of treatment. Night-time sleep, daytime > somnolence, and quality of life all improved. > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn