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I appreciate your advice regarding magnesium oxide, Arnie! Yes, I have stopped using it...But I wonder...are there specific professions/occupations that show a high incidence of pd that you are aware of (like, say, potters or x-ray technicians, etc.)? Assuming there is an environmental trigger... Interesting comments about controlled variables, as well. Regardless, thanks for your comments. joan As a footnote, what is interesting about your post is that I received it even though I did not receive my own post to the list (the one you responded to)...not sure why. ----- Original Message ----- From: "Arnie Kuzmack" <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, June 23, 2006 4:46 AM Subject: Re: Manganese, well water, and PD >> Just to let you know, manganese oxide (in powder form) >> is a glaze ingredient used by potters. I have worked alot with >> clay and used to use as a colourant on clay sculptures. I would >> drop an arbitrary amount of powder into water and then dip a >> sponge into this solution to dab onto fired clay. The material >> data sheet clearly states that it can be absorbed directly >> through >> the skin into the nervous system. This fact has caused some >> potters to stop using it. >> >> I do not have pd but always wonder if using it has put me at >> risk. > > I have not done a study of the literature, but, as a precaution, > it can't hurt to stop using it. Toxicologically, dermal > absorption is very different from ingestion. With ingestion, the > digestive tract functions to control the degree of absorption > into the blood. With dermal absorption, it goes directly into > the blood. > >> Juut as an aside, my mother did have pd and most of her adult >> life >> craved liver which of course is high in iron. Is there any >> correlation >> to iron-rich diet from organ meets and pd? > > The study cited by Maryse (attached to your message) purports to > show a correlation. However, it is unclear what other variables > were controlled and what lead to the high intake levels of iron > and managanese. See my other comments below. > > As is frequently the case with this sort of study, we do not know > whether the high intakes played a role in causing the disease or > whether, alternatively, a predisposition to PD caused the craving > for liver, or whether some other factor palyed a role in causing > both. > > Therefore, we can't say that your mother would have been better > off to resist her craving. We just don't know. > > >>>>> [Arnie] Ingested manganese is an essential nutrient. There >>>>> is very >>>>> little evidence of adverse neurological effects of ingested >>>>> manganese. >>>> >>>> >>>> [Maryse] it could be risky: >>>> >>>> [Maryse] >>>> http://www.neurology.org/cgi/content/abstract/60/11/1761 >>> >>> [Arnie] Before drawing any conclusions, one would want to >>> know more about >>> these populations and, in particular, what led some of them to >>> consume a lot more iron and manganese than the rest. Was >>> there >>> something about their sociological or other lifestyle >>> characteristics that would occur disproportionately among >>> people >>> in this area who consume larger amounts of iron and manganese >>> than others? >>> >>> [Arnie] While I don't have the full article, the abstract >>> does not >>> mention controlling for other variables, not even smoking and >>> alcohol consumption (known to be related to PD risk) or >>> correcting for multiple comparisons (where testing a large >>> number >>> of variables can lead to false positives.) > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn