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NICOTINE MAY PROTECT AGAINST PARKINSON’S DISEASE The protective effect may explain the lower incidence of Parkinson’s disease among smokers and suggests that nicotine may be useful in the treatment of early-stage Parkinson’s patients. Parkinson’s disease is a progressive, neurodegenerative disease caused by the death of small clusters of cells in the midbrain. The gradual loss of these cells results in reduction of a critical transmitter called dopamine, the chemical messenger responsible for normal movement. “While we would never recommend that people smoke, these results suggest that nicotine promotes the survival of dopamine-producing cells in animals with no overt Parkinson’s symptoms,” said David A. Schwartz, M.D., director of the National Institute of Environmental Health Sciences, the federal agency that provided funding for the study. “These findings also have implications for its use in slowing the progression of Parkinson’s.” Most of the research on tobacco has focused on its detrimental health effects. However, studies conducted over the last 40 years show that the incidence of Parkinson’s disease is about 50 per cent less in smokers than in the general population. “These studies were giving us clues that something in the smoke was reducing the incidence of Parkinson’s,” said Maryka Quik, Ph.D., a senior research scientist with The Parkinson’s Institute and lead author on the study. Based on these findings, the researchers wondered what compound in cigarette smoke could be causing this effect. “We decided to focus our attention on nicotine because studies have shown that nicotine stimulates the release of dopamine in the brain region that is associated with Parkinson’s,” said Quik. Results from the five-year study, conducted by researchers at The Parkinson’s Institute, California (USA), are published in an on-line early release in the Journal of Neurochemistry. To test their theory, the researchers treated experimental animals with MPTP, an agent that selectively destroys the dopamine-producing brain cells. Half of the animals also received a low-dose administration of nicotine over a six-month period. During this time, the nicotine dose was gradually increased to a level typically found in cigarette smoke. The test results showed that animals receiving only the MPTP suffered a 75 percent loss of function in their dopamine-containing brain cells. When the researchers tested the animals that had received both MPTP and nicotine, the damage in the dopamine cells was only 50 per cent. “The results suggested that the nicotine treatment had reduced the cell damage by 25 per cent,” said Quik. While there is no immediate explanation for this effect, the researchers believe the nicotine may stimulate the release of naturally occurring proteins called growth factors that play a key role in nerve cell growth and repair. “It is also possible that the nicotine may activate the immune system to protect the cells from MPTP-induced damage,” said Quik. According to Quik, Parkinson’s disease symptoms only start to develop when 80 to 90 per cent of dopamine in striatal nerve terminals is depleted. “This means that a reduction in terminal damage from 80 to 60 percent can mean the difference between having disease symptoms and being symptom-free,” said Quik. While treatments currently available for Parkinson’s disease are limited to the day to day relief of symptoms, nicotine may someday be used to reduce or even prevent the progression of the disease. “With current symptomatic therapies, the progress of the disease is not halted and, symptoms become worse and more difficult to control,” said Quik. “With neuroprotection, a patient could receive treatment that would halt the disease progress and prevent symptoms from getting worse.” Reference: M. Quik, N. Parameswaran, S.E. McCallum, Bordia T, Bao S, McCormack, Kim A, Tyndale RF, Langston JW, Di Monte DA. Chronic Oral Nicotine Treatment Protects Against Striatal Degeneration in MPTP-Treated Primates. Journal of Neurochemistry, on-line early release doi:10.1111/j.1471-4159.2006.04078.x ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn