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Hi Lynn, Welcome to the Parkinsn List. I'm sure different people will have different replies to you about medication. Depends a lot on what you are taking and for how long. Most people find Sinemet becomes more unpredictible in how well and for how long it is effective, after taking it about 5 years or so. And it can vary from day to day, even hour to hour. If you do not feel like your meds are working though you should talk to your neuro about it. Frequently adjustments may be needed. Welcome again and hope you will find this list helpful. Linda Herman -- ROBERT PITTS <[log in to unmask]> wrote: Hello, my name is Lynn. I was diagnosed with PD 3 years ago. I found this group when I was looking up some information on PD. I Am hoping to get some helpful feedback from others who also have the disease How is the medication working for others? It doesn't seem to help me much. Should it make the tremors quiet down completely? I'm sure I will have lots of other questions, but they will come later. Thanks in advance......Lynn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn