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I agree, every time i am introduced to a new neuro i make it quite clear that i feel they should and could get a nobel for discovering the cause(s) of pd. but i also realize that an obscure piece of mundane research may lead to this. \Randy Games to entertain your brain. http://www.stargraphics.com Star Graphics Corp 10943 S Forest Ridge Ln Oregon City, OR 97045 ----- Original Message ----- From: "mackenzie" <[log in to unmask]> To: <[log in to unmask]> Sent: Monday, September 04, 2006 11:50 PM Subject: Re: glutamate antagonist > what we need is a new paradigm - one in which the idea > is not "how can we reduce dyskinesias" but "hey, > here's an idea! why didn't we think of this before? > what if we could come up with something that *didn't > cause* dyskinesias? and lose efficacy really fast and > cause motor fluctuations? wouldn't that be so cool?" > > after all, they have been trying to fix dyskinesias > (etc.) for almost 40 years - they are still trying > (i.e., their efforts have been failing for 40 years) > > yes, there is research going on into areas other than > "bandaids for levodopa" but at my last really rough > estimate, there is something in the neighborhood of $1 > billion worth of levodopa bandaid studies listed on > clinicaltrials.gov (both completed and ongoing, and > that is assuming they are all Phase I (i.e., the > cheapest) trials - which they are not.) > > $1 billion is a lot of money to still be spending on > something that, while better than nothing, is > seriously broken, particularly when that money could > be allocated to other therapies - ones that would need > fewer bandaids. > > call it my billion dollar bugaboo. > > > --- Randy L Vinecore <[log in to unmask]> wrote: > >> The lead researcher in a study of cp101,606 said >> that although they are >> still looking at the data it looks like this >> substance decreases dyskinesia. >> But as is often the case with this sort of thing it >> might increase the >> parkinsons symptoms. I was the third primate (and >> the first human) to try >> this subtance. It would have to be re-engineered to >> be marketed as it has >> to be delivered iv in it's current form. >> \Randy >> >> > ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn >> > > > __________________________________________________ > Do You Yahoo!? > Tired of spam? Yahoo! Mail has the best spam protection around > http://mail.yahoo.com > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn