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Well, clearly the validity and solidity of the studies themselves is irrelevant - press coverage, one's personal experience, and anecdote are all that is needed. If researchers can publish studies as poorly done (to be extremely generous) as these and no one cares, is it any wonder so little progress has been made in the last 40 years? They can do whatever they want - no one is paying attention, no one cares, and they are accountable to no one. The tragedy will be anyone who passes over a dopamine agonist, or worse yet, is never offered one, in favor of levodopa, and in so doing swaps an extremely debatable, and, if it even exists, miniscule elevation in the danger of engaging in compulsive behavior for the - particularly if one is on the younger side - virtual certainty of the worst of levodopa within five years, a certainty one will spend the rest of one's life trying (and largely failing) to manage and a certainty that could have been delayed for several precious years. "M.Schild" <[log in to unmask]> wrote: I should think the main outcome of all these studies is not which agonist is the culprit but the fact that by changing or stopping the involved agonist, the compusion diminishes or stops. That is the important part. Other side effects are not so easy to get rid of unfortunately so why argue the fact that some compulsive behaviour can be due to agonists and something can be done about it? Compulsions take many forms Maryse ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn --------------------------------- ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn Yahoo! Messenger with Voice. Make PC-to-Phone Calls to the US (and 30+ countries) for 2¢/min or less.