Bruce, welcome to our group. I took Sinemet and it helped once, took it for a year with no improvement. 3 years ago I had DBS brain surgeries which control tremor at expense of losing my voice. I can barely walk and my hands are like paws, but I don't take any PD meds at all and live alone. I'm not pushing DBS but some people have had outstanding results, others not so good. You probably know all this being a Prof of Neuroscience, but wanted you to know first hand it really does help tremor, both essential and PD. The problem I have also is with dental work - you can't get drills near neurotransmitters so I have had extractions and may soon be gumming it. Ray ----- Original Message ----- From: "Bruce Walmsley" <[log in to unmask]> To: <[log in to unmask]> Sent: Thursday, November 23, 2006 3:55 PM Subject: new member - Bruce > Hi - I am a Professor of Neuroscience at The John Curtin School of Medical > Research at The Australian National University in Canberra, Australia. I > was diagnosed with PD in my late forties - I am now 57. At first I took > cabergoline, a dopamine D2 agonist. This made little difference to my > symptoms (mostly tremor). I am now on sinemet, which is great. However, > over the past 3-4 years I developed severe psychosis - mostly paranoid > delusions - and was hospitalized a number of times. The psychotic episodes > were frightening for myself and my family. Luckily for me, my wife is a > wonderful person and she managed to hold our family together (we have a > teenage daughter and a teenage son). Tracking back, it appears that the > dopamine agonist was to blame, because shortly after I stopped taking it, > I returned to normal with no psychosis. I hope it stays that way ! > I would be interested in other people's experiences with dopamine > agonists. I am hopeful that research into PD will lead to more effective > treatments - it looks promising and I am optimistic. > I am looking forward to interacting with others who have PD. > Cheers, > Bruce > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn