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It is common with all dopamine agonists. I have taken 3 of them over the years (Requip, Mirapex, and a Lisuride transdermal patch in a clinical trial) and observed it with all 3. It is particularly serious if you drive and can be a problem in a work or social situation. You can take drugs to counteract it. I found Provigil was particularly effective, but it cost $3,000 a year and my insurace would not cover it. I am now taking Ritalin and it works pretty well. Here are several abstracts of articles in the medical literature on the subject. Abstracts can be found on PubMed: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=journals Ondo WG, Fayle R, Atassi F, Jankovic J. Modafinil for daytime somnolence in Parkinson's disease: double blind, placebo controlled parallel trial. J Neurol Neurosurg Psychiatry. 2005 Dec;76(12):1636-9. PMID: 16291885 Comella CL. Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview. J Neural Transm Suppl. 2006;(70):349-55. Review. PMID: 17017552 [PubMed - indexed for MEDLINE] Gjerstad MD, Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP. Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? Neurology. 2006 Sep 12;67(5):853-8. PMID: 16966550 [PubMed - indexed for MEDLINE] Borek LL, Kohn R, Friedman JH. Mood and sleep in Parkinson's disease. J Clin Psychiatry. 2006 Jun;67(6):958-63. PMID: 16848656 [PubMed - in process] Monaca C, Duhamel A, Jacquesson JM, Ozsancak C, Destee A, Guieu JD, Defebvre L, Derambure P. Vigilance troubles in Parkinson's disease: a subjective and objective polysomnographic study. Sleep Med. 2006 Aug;7(5):448-53. Epub 2006 Jun 5. PMID: 16740409 [PubMed - indexed for MEDLINE] Ferreira JJ, Desboeuf K, Galitzky M, Thalamas C, Brefel-Courbon C, Fabre N, Senard JM, Montastruc JL, Sampaio C, Rascol O. Sleep disruption, daytime somnolence and 'sleep attacks' in Parkinson's disease: a clinical survey in PD patients and age- matched healthy volunteers. Eur J Neurol. 2006 Mar;13(3):209-14. PMID: 16618334 [PubMed - indexed for MEDLINE] Rye DB. Excessive daytime sleepiness and unintended sleep in Parkinson's disease. Curr Neurol Neurosci Rep. 2006 Mar;6(2):169-76. Review. PMID: 16522272 [PubMed - indexed for MEDLINE] Wegelin J, McNamara P, Durso R, Brown A, McLaren D. Correlates of excessive daytime sleepiness in Parkinson's disease. Parkinsonism Relat Disord. 2005 Nov;11(7):441-8. Epub 2005 Sep 9. PMID: 16154796 [PubMed - indexed for MEDLINE] Moller JC, Rethfeldt M, Korner Y, Stiasny-Kolster K, Cassel W, Meindorfner C, Rissling I, Kruger HP, Oertel WH. Daytime sleep latency in medication-matched Parkinsonian patients with and without sudden onset of sleep. Mov Disord. 2005 Dec;20(12):1620-2. PMID: 16078226 [PubMed - indexed for MEDLINE] Arnulf I. Excessive daytime sleepiness in parkinsonism. Sleep Med Rev. 2005 Jun;9(3):185-200. Epub 2005 Apr 26. Review. PMID: 15893249 [PubMed - indexed for MEDLINE] Meindorfner C, Korner Y, Moller JC, Stiasny-Kolster K, Oertel WH, Kruger HP. Driving in Parkinson's disease: mobility, accidents, and sudden onset of sleep at the wheel. Mov Disord. 2005 Jul;20(7):832-42. PMID: 15726539 [PubMed - indexed for MEDLINE] Kaynak D, Kiziltan G, Kaynak H, Benbir G, Uysal O. Sleep and sleepiness in patients with Parkinson's disease before and after dopaminergic treatment. Eur J Neurol. 2005 Mar;12(3):199-207. PMID: 15693809 [PubMed - indexed for MEDLINE] Romigi A, Brusa L, Marciani MG, Pierantozzi M, Placidi F, Izzi F, Sperli F, Testa F, Stanzione P. Sleep episodes and daytime somnolence as result of individual susceptibility to different dopaminergic drugs in a PD patient: a polysomnographic study. J Neurol Sci. 2005 Jan 15;228(1):7-10. Epub 2004 Nov 10. PMID: 15607203 [PubMed - indexed for MEDLINE] ----- Original Message ----- From: "M.Schild" <[log in to unmask]> To: <[log in to unmask]> Sent: Monday, January 01, 2007 2:53 AM Subject: Re: Question regarding Requip > I justed started taking Requip to supplement the levodopa. I > experienced a > lot of drowsiness that last for 1.5 hrs plus. Wondering if this > is normal. I think a lot of people experience somnolence with Requip. Sometimes it goes, sometimes not maryse cg JOhn 77,17 ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn