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I also have experienced sleepy times usually about 20 min after taking the drug. I talk a rest for about 15 min and seem to be able to function after that. Does anyone experience swelling in the ankles???? This is a big problem for me but I like the drug effects on the tremors. A dilemma for me. Cathy ----- Original Message ----- From: "Arnie Kuzmack" <[log in to unmask]> To: <[log in to unmask]> Sent: Monday, January 01, 2007 11:18 AM Subject: Re: Question regarding Requip > It is common with all dopamine agonists. I have taken 3 of them > over the years (Requip, Mirapex, and a Lisuride transdermal patch > in a clinical trial) and observed it with all 3. It is > particularly serious if you drive and can be a problem in a work > or social situation. > > You can take drugs to counteract it. I found Provigil was > particularly effective, but it cost $3,000 a year and my insurace > would not cover it. I am now taking Ritalin and it works pretty > well. > > Here are several abstracts of articles in the medical literature > on the subject. Abstracts can be found on PubMed: > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=journals > > Ondo WG, Fayle R, Atassi F, Jankovic J. > Modafinil for daytime somnolence in Parkinson's disease: double > blind, placebo controlled parallel trial. > J Neurol Neurosurg Psychiatry. 2005 Dec;76(12):1636-9. > PMID: 16291885 > > Comella CL. > Sleep disturbances and excessive daytime sleepiness in Parkinson > disease: an overview. > J Neural Transm Suppl. 2006;(70):349-55. Review. > PMID: 17017552 [PubMed - indexed for MEDLINE] > > Gjerstad MD, Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP. > Excessive daytime sleepiness in Parkinson disease: is it the > drugs or the disease? > Neurology. 2006 Sep 12;67(5):853-8. > PMID: 16966550 [PubMed - indexed for MEDLINE] > > Borek LL, Kohn R, Friedman JH. > Mood and sleep in Parkinson's disease. > J Clin Psychiatry. 2006 Jun;67(6):958-63. > PMID: 16848656 [PubMed - in process] > > Monaca C, Duhamel A, Jacquesson JM, Ozsancak C, Destee A, Guieu > JD, Defebvre L, Derambure P. > Vigilance troubles in Parkinson's disease: a subjective and > objective polysomnographic study. > Sleep Med. 2006 Aug;7(5):448-53. Epub 2006 Jun 5. > PMID: 16740409 [PubMed - indexed for MEDLINE] > > Ferreira JJ, Desboeuf K, Galitzky M, Thalamas C, Brefel-Courbon > C, Fabre N, Senard JM, Montastruc JL, Sampaio C, Rascol O. > Sleep disruption, daytime somnolence and 'sleep attacks' in > Parkinson's disease: a clinical survey in PD patients and age- > matched healthy volunteers. > Eur J Neurol. 2006 Mar;13(3):209-14. > PMID: 16618334 [PubMed - indexed for MEDLINE] > > Rye DB. > Excessive daytime sleepiness and unintended sleep in Parkinson's > disease. > Curr Neurol Neurosci Rep. 2006 Mar;6(2):169-76. Review. > PMID: 16522272 [PubMed - indexed for MEDLINE] > > Wegelin J, McNamara P, Durso R, Brown A, McLaren D. > Correlates of excessive daytime sleepiness in Parkinson's > disease. > Parkinsonism Relat Disord. 2005 Nov;11(7):441-8. Epub 2005 Sep 9. > PMID: 16154796 [PubMed - indexed for MEDLINE] > > Moller JC, Rethfeldt M, Korner Y, Stiasny-Kolster K, Cassel W, > Meindorfner C, Rissling I, Kruger HP, Oertel WH. > Daytime sleep latency in medication-matched Parkinsonian > patients with and without sudden onset of sleep. > Mov Disord. 2005 Dec;20(12):1620-2. > PMID: 16078226 [PubMed - indexed for MEDLINE] > > Arnulf I. > Excessive daytime sleepiness in parkinsonism. > Sleep Med Rev. 2005 Jun;9(3):185-200. Epub 2005 Apr 26. Review. > PMID: 15893249 [PubMed - indexed for MEDLINE] > > Meindorfner C, Korner Y, Moller JC, Stiasny-Kolster K, Oertel WH, > Kruger HP. > Driving in Parkinson's disease: mobility, accidents, and sudden > onset of sleep at the wheel. > Mov Disord. 2005 Jul;20(7):832-42. > PMID: 15726539 [PubMed - indexed for MEDLINE] > > Kaynak D, Kiziltan G, Kaynak H, Benbir G, Uysal O. > Sleep and sleepiness in patients with Parkinson's disease before > and after dopaminergic treatment. > Eur J Neurol. 2005 Mar;12(3):199-207. > PMID: 15693809 [PubMed - indexed for MEDLINE] > > Romigi A, Brusa L, Marciani MG, Pierantozzi M, Placidi F, Izzi F, > Sperli F, Testa F, Stanzione P. > Sleep episodes and daytime somnolence as result of individual > susceptibility to different dopaminergic drugs in a PD patient: a > polysomnographic study. > J Neurol Sci. 2005 Jan 15;228(1):7-10. Epub 2004 Nov 10. > PMID: 15607203 [PubMed - indexed for MEDLINE] > > > ----- Original Message ----- > From: "M.Schild" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Monday, January 01, 2007 2:53 AM > Subject: Re: Question regarding Requip > > >> I justed started taking Requip to supplement the levodopa. I >> experienced a >> lot of drowsiness that last for 1.5 hrs plus. Wondering if this >> is normal. > > > I think a lot of people experience somnolence with Requip. > Sometimes it goes, > sometimes not > maryse cg JOhn 77,17 > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn