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Stem cell therapy cures Parkinson's patient
Jangveer Singh
Tribune News Service
Bangalore, April 4
Indian stem cell researchers at the Manipal hospital here today announced
the first worldwide case of a recovery from Parkinson's disease by use of
stem cells from the patient's own body.
The claim is significant because the patient, Andrew Kisana, a US citizen of
Pakistani origin, had come to Manipal hospital for treatment for Parkinson's
disease after receiving both conventional as well as surgical treatment for
the disease in the US. "This is clearly the first such clearly documented
case in which a patient has recovered from Parkinson's disease after the use
of stem cells", hospital managing director R. Basil disclosed.
Andrew's recovery is significant. His daughter Kusma told TNS that her
father found it difficult to walk and was dragging his right leg when he was
admitted to the Manipal hospital last year. Andrew had found it difficult to
swallow and even breathe when he was admitted to the hospital.
Andrew walked unaided to meet mediapersons today. Though his speech has
improved, it is still slightly blurred. So he put across his thoughts via
his laptop. Andrew said since his treatment here his general muscle strength
had improved as had his gait, handwriting and bowel movements. He can walk
unaided, which was impossible earlier and his tremors have reduced
significantly.
Andrew said earlier though his motor skills had improved after a deep brain
stimulation surgery conducted on him in the USA, he started having side
effects, including severe laryngeal spasms. He said the current treatment
had ensured an end to these spasms also. Andrew has been off all drugs for
Parkinson's disease since the past six months.
Explaining how this came about, hospital's nuerological disease institute
head Dr N.K Venkataramana said Andrew had received three injections of
isolated mesenchymal cells which had been harvested from his bone marrow. As
many as 1.5 million of these stem cells had been transplanted into his
brain. He said each injection cost Rs 75,000 adding that the cost could be
reduced at a later stage.
Dr Venkataramana said stem cell research seemed to be promising in
regenerating hope to cure Parkinson's disease as the present treatment at
the best removed some of the symptoms but did not stop the progression of
the disease. He said the present initiative would motivate patients across
the world to explore this new modality which did not involve any issue of
ethics as adult stem cells were used. "However, we need to observe the long
term clinical effects in large number of patients to decide its role in the
treatment of degenerative diseases", he added.

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