Emily I also have extreme fatigue associated with Parkinson's disease. Wellbutrine XL took care of the apathy and rage, but even though I felt good I interested in doing things, But I lacked the energy to go to work every day. I lacked mental focus when I was run down and was a dangerous driver ( thank fully I never hurt anyone). My Neuro. started me on 100mg of Provigil to help with mental acuity. It works well for that and sleepy ness but not for the overwhelming fatigue. What appears to be working for that is 600 mg of Coenzyme Q10, plus 359 mg of mixed tocopherols with 26.9 iu's of vitamin E. and 1800 mg of Ashwaganda ( it's an East Indian herb). All that twice a day. It seems like a lot of capsules to take and it's not cheap but it's been worth it. I can shoot a two day archery tournament with out loosing focus or fatiguing out. It takes a couple of days to recover, but I can still do those things I enjoy. It's not just the supplements that allow me to shoot though. I have a Bi-lateral Deep Brain Stimulator and take 1mg of Azilect. to treat the traditional symptoms of PD. Sincerely Chris Tittle P.S. I only take Provigil if I'm going to be driving, shooting or something that requires alertness. In addition Provigili is an off label prescription for PD. In order to get my prescription plan to pay for it, my Neuro. had to prescribe it "for mental dullness". I wasn't thrilled with that, but it worked At 04:16 AM 4/13/2007, you wrote: >Hi there > >I am joining this list as my father-in-law has Parkinson's. I would like to >know more about Parkinson's medicines - what have folks tried, what has >seemed to work, etc. My father-in-law, Charles, is interested in finding out >if anyone suffers from extreme fatigue and what they do about it. > >I'm just thankful that something like this exists and look forward to >"meeting" some of you and learning more. > >Thanks >Emily > > > > > >---------------------------------------------------------------------- >To sign-off Parkinsn send a message to: mailto:[log in to unmask] >In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn