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Who Cares. What a lopsided study!!. Another example of the establishment trying to dissuade the public from doing something beneficial for themselves. Anyone taking CoQ 10 knows to have beneficial effects for functional energy improvement and symptomatic improvement one must take tyrosine , nacetyl cysteine, alpha lipoic acid, carnitine, niacin, coenzyme one just to mention a few as precurers for the production of dopamine and support for the functional relief of symptoms. This study is about as much use as trying to drive a car on one wheel. Its really nice to know the "people" in the know are still trying to back door us every time we get something that gives us Hope and Help. It all goes back to the old adage " if you want something done , better do it yourself" . Research and doctors promise the cure and do very little about help except to push pills. Rob ----- Original Message ----- From: M.Schild <[log in to unmask]> To: <[log in to unmask]> Sent: Monday, May 14, 2007 10:49 PM Subject: Coenzyme Q10 Does Not Improve Parkinson's Disease Symptoms > May 14, 2007 > Coenzyme Q10 Does Not Improve Parkinson's Disease Symptoms > Science Daily — Small doses of the antioxidant coenzyme Q10 appear to increase > blood levels of this naturally occurring compound in patients with > Parkinson's disease, but does not improve Parkinson's disease symptoms, > according to an article that will appear in the July 2007 print issue of > Archives of Neurology, one of the JAMA/Archives journals. > > > Parkinson's disease is a neurodegenerative disorder characterized by tremors > and difficulty with walking or other movements. The biological mechanisms > underlying the condition are not fully understood, but researchers suspect a > malfunction of the mitochondria, parts of the cells that help convert food to > energy, according to background information in the article. > Coenzyme (CoQ10), an antioxidant sold as a dietary supplement, is also > involved in mitochondrial processes. "Because of these functions, CoQ10 has > attracted attention concerning neuroprotective actions in neurodegenerative > disorders linked to mitochondrial defects or oxidative [oxygen-related] > stress, such as Huntington's disease and Parkinson's disease," the authors > write. Previous studies indicate that high doses of CoQ10 (1,200 milligrams) > may slow the deterioration associated with Parkinson's disease. > Alexander Storch, M.D., of the Technical University of Dresden, Germany, and > colleagues conducted a randomized clinical trial of a 300-milligram dose of > CoQ10 in 131 patients with Parkinson's disease who did not have changes in > motor functions and were on stable treatment for their condition. Those > assigned to the treatment group took 100 milligrams of CoQ10 three times > daily for three months, followed by a two-month "washout" period. The > researchers assessed Parkinson's disease symptoms before treatment began, > each month during treatment and again after the washout period. Blood tests > were performed at the beginning of the study, after three months of treatment > and after the washout period. > A total of 106 patients completed the full three months of the study--55 in > the CoQ10 group and 51 in the placebo group. The compound was well tolerated > overall, and the percentage of patients who experienced adverse > effects--including viral infection, diarrhea and hearing loss--did not differ > between the two groups. Blood levels of CoQ10 increased in the treatment > group from an average of 0.99 milligrams per liter to an average of 4.46 > milligrams per liter after three months. > "Although we demonstrated a significant increase in plasma levels of CoQ10 > toward levels observed with high doses of standard CoQ10 formulations in > Parkinson's disease and other disorders, our study failed to show improvement > of Parkinson's disease symptoms and did not meet its primary or secondary end > points," which were changes on scales that measured Parkinson's disease > symptoms and their effects on physical and mental functioning, the authors > write. "Our study further demonstrated that 300 milligrams per day of > nanoparticular CoQ10 is safe and well tolerated in patients with Parkinson's > disease already taking various antiparkinsonian medications." > "Since we did not find symptomatic effects of CoQ10 in Parkinson's disease, > our study does not support the hypothesis that restoring the impaired energy > metabolism of the diseased dopaminergic neurons leads to symptomatic benefits > in Parkinson's disease," the authors conclude. "Future studies will need to > explore the protective effects of CoQ10 at the highest effective dose > (equivalent to about 2,400 milligrams per day of a standard formulation) over > a long treatment period and in a large cohort of patients both sufficient to > clearly define the protective potential of this compound in Parkinson's > disease." > Arch Neurol. 2007;64:(doi:10.1001/archneur.64.7.nct60005). > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn