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Ray I'm going to go out on a scary limb here. Dopamine is a neuro-transmitter, one of many identified in our brain. Highly specialized chemicals these - each with a specific task - except (it seems) dopamine. Dopamine is the transmitter of mood and movement. Or is it? I don't know of another dual purpose neuro-transmitter. Do you? Perhaps there's a fundamental reason that sinemet and the agonist drugs give us strange side effects before losing what effectiveness they had and failing entirely. Have our researchers been barking up the wrong tree? -- Steve Rack ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn Brattleboro VT