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Parkinson's genomic pathway discovered
 ROCHESTER, Minn., June 18 (UPI) --  U.S. scientists have discovered
a "genomic pathway" that can be used to predict the risk of developing
Parkinson's disease, as well as the age of onset.
 The Mayo Clinic study suggests the joint effects of common DNA variations in
several genes that encode proteins within a biological pathway largely
explain why some people develop Parkinson's disease while others do not --
and can be used to even predict, with great accuracy, at what age a person
might develop their first symptoms.
 "This represents a major paradigm shift from single gene studies to genomic
pathway studies of complex diseases," said Dr. Demetrius Maraganore, a Mayo
Clinic neurologist and Parkinson's disease specialist who led the study.
 The findings are published in the June 15 issue of PLoS Genetics.

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