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In a message dated 22/06/2007 07:02:32 GMT Standard Time, [log in to unmask] writes: Amanda, I used to shake more when involved in music...singing or playing the piano. Weird, just the opposite from you...wonder why. Ray Rayilyn Brown Board Member AZNPF Arizona Chapter National Parkinson's Foundation [log in to unmask] ----- Original Message ----- From: "Amanda Phillips" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, June 20, 2007 3:37 PM Subject: Re: barking up the wrong tree > In a message dated 20/06/2007 07:01:44 GMT Standard Time, > [log in to unmask] > writes: > > Steve > > I have long failed to understand the role of dopamine in PD but then my > education has been in the social, not biological, sciences. > > I ask: > > How do they know I'm lacking dopamine when there is no blood test to > measure > how much I have? (and I don't want to wait til I die to find out) > > Why if lack of dopamine caused my tremors do leads in my brain that > constantly transmit electric impulses from neurotransmittters in my chest > stop them? And how was DBS able to immediately straighten out my > dystonic > foot? Since DBS 4 ago years I've kind of plateaued except for my voice. > > I don't think the disease process is understood at all, even though > they > say it is, but then what do I know? > > And I don't buy that you've lost 80% of your dopamine before you become > symptomatic. If lack of it is the cause, how do you function so long > without the right amount whatever that might be? > > Why do PD meds affect people so differently? A few years ago Edith Love > and > Mario attempted to develop a data base to share info. We need something > at > least nationally. > > Ray > > Rayilyn Brown > Board Member AZNPF > Arizona Chapter National Parkinson's Foundation > [log in to unmask] > ----- Original Message ----- > From: "Steve Rack" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Monday, June 18, 2007 8:31 PM > Subject: barking up the wrong tree > > >> Ray I'm going to go out on a scary limb here. Dopamine is a >> neuro-transmitter, one of many identified in our brain. Highly >> specialized chemicals these - each with a specific task - except (it >> seems) dopamine. Dopamine is the transmitter of mood and movement. Or >> is it? I don't know of another dual purpose neuro-transmitter. Do >> you? Perhaps there's a fundamental reason that sinemet and the >> agonist drugs give us strange side effects before losing what >> effectiveness they had and failing entirely. Have our researchers >> been barking up the wrong tree? >> -- >> Steve Rack >> >> ---------------------------------------------------------------------- >> To sign-off Parkinsn send a message to: >> mailto:[log in to unmask] >> In the body of the message put: signoff parkinsn >> Brattleboro VT >> > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > > > > Why do I stop shaking when really absorbed in playing music ? There > isn't > much time for brain chemistry to change - the doctors just said 'you must > be > mistaken -no\I'm not. > > How come only humans get pd ? A matter of intelligence ? if so, what > role > exactly does intelligence play in developing PD ? > > > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn Concentration ? I love music but have no talent so must use obstinacy instead, or maybe it's just different brain configurations. Like you I'm not convinced about dopamine, 'cos I don't see how it accounts for the variations - and what's with the freezing in doorways ( a bloke in my local support group can't go through glass doors) or forgetting how to go from kneel to stand ? The doctors probably can't measure it before or after death. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn