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My experience with that much Sinement is that he is overdosed. he effects of overdose are worse than under-dose .try suffering through the overdose time and wait to medicate when you indicate that the tremors are of different type. My tremors switch sides. My neuro suggested half as much as I was taking . I don't always have good luck but I can be tremor free for three or four hours. Taking sinement 30 minutes before a meal and I can hardly eat. I use Amantadine and a couple other drugs. Regards, Bill Lawless [Post hoc, ergo propter hoc!] a logical fallacy. ----- Original Message ----- From: Annette Barrackman To: [log in to unmask] Sent: Monday, July 30, 2007 12:32 AM Subject: Re: Weight Loss My husband has also experienced significant weight loss and a newly-gained capacity to NOT put on weight since the worsening of his Parkinson's symptoms several years ago. He currently takes 5 sinemet 25/100 + 5 sinemet 50/200 daily. He has severe tremors (bilateral -- arms, hands, legs/feet + head) and also has essential tremor (has action, intention and resting tremors) and he has lost the most weight at the time when his tremors have been the worst -- I think both because of calories burned through the constant shaking and because of the fact that bad tremors make it difficult for him to eat. L-dopa related nausea/loss of appetite doesn't help. He also suffers from periodic episodes of severe depression (which are sometimes associated with total loss of appetite and other times associated with an uncontrollable urge to eat tons of ice cream). Annette, wife & caregiver of Ken On 7/16/07, Nick <[log in to unmask]> wrote: > > My wife is a 15 year Parkie. She started losing weight about a year ago, > and has gone from 105 to 85. She has a good appetite, eats a balanced > diet. She is still losing weight. She takes amantidine , 2tabs twice a > day, and 2 sinemet 25/100 before bedtime. Has this happened to any other > Parkies? Is this directly related to her Parkinson's disease? Please help. > > Nick > husband & caregiver > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn In the body of the message put: signoff parkinsn