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Hi, Here is another update for those of you who are interested. I have been using Neupro Rotigotine Transdermal patches since May 10th, as an alternative to Mirapex..I started on the lowest dose 2mg/24hr, and am now on the highest dose 8mg/24hrs. The most obvious benefit is a big reduction in duration and strength of dyskenesia, it is still there, but much less of a problem. also it means 3 less tablets per day.The negative points are, off times are now really off, can't walk or get out of my chair, so I have had to increase the frequency Madopar from 3 times a day to 4 times a day to try and counter this. Also I find it is difficult to make the patches stay in place, I have found that using strips of elasticated tubular bandages ensures that they stay on. My Neuro' recently suggested I try Entacapone as well, in an attempt to prolong the "On" times, but all it has done is increase the dyskenesia to an uncomfortable level., so I will stop taking that. Conclusion: On balance I would say it has been worthwhile changing onto Rotigotine, if only because of the drastic reduction of the hated dyskenesia., but the increase in severity of "Off " time is a big negative point. Nigel. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn