Thanks, Linda, for alerting me to the discussion on this new therapy. I receive a digest via my email and don't always read every post. Here's yet another reason why PD is called the "designer" disease - it is different in everyone AND medications or treatments react differently in everyone. Let me give my background: I was diagnosed at 44, but had symptoms much earlier. After about 5 1/2 years, I was going downhill fast so I entered a clinical trial (Spheramine) where retinal cells (from a donor) that produced dopamine were implanted into my brain. It was up and down, but after 7 years I definitely have seen benefit of the surgery. Now it's been 12 years since diagnosed and I just started "freezing." I don't mean the hesitation you often get when coming to a doorway or get in tight spots, but FREEZING, especially in the mornings. I tried a little more Sinemet which helped during the day, but the mornings I could barely walk at all. Then the doctor let me try the rotigotine patch (Neupro). He gave me samples of 2 - 4 and 6 mg. I tried 2 mg for a week - nothing happened. But in just a week's time on the 6 mg my morning freezing is almost nil. So it seems to be working for me. I hear that Requip (which I take) is coming out with a control-released pill which will probably do the same thing. However, the patch is very convenient. Now a question. Does my reaction mean that I am still making dopamine, but my receptors just needed a boost? I think that's what the agonists do - stimulate your receptors so you receive more dopamine. Thanks again for the discussion. Since Neupro is a new product, your physicians should have samples on hand - ask about it. You may have my same success. Peggy ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn