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Hello I have had symptoms (tremor & shuffle walk) for almost three years and was diagnosed with PD 16 months ago. Since that time, I have tried Selegiline, Sinamet, Artane, Mirapex, Baclofen and Neupro patches. None of these reduced the tremor or improved my walk and all of them had serious side effects on my digestive system (nausea/reflux to the extent I could not eat and in some cases could not get out of bed). Another medication, Metoprolol, for chest pain did lessen the tremor but aggravated my asthma and liver disease. My question is; has anyone experienced depression related to PD and what medication has been effective? My wife and our family therapist are both asking me to seriously consider an antidepressant to aid my sleep depravation/muscle tightness and my primary care physician has prescribed Ambien. My neurologist/movement disorder specialist has not been willing to prescribe an antidepressant so far. I see him again on Tuesday. We depart for three months in Sarasota on 12 January. Rick Knittel South Portland, Maine ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn