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Doctors Working On Vaccine For Parkinson's

Not a cure, but aimed at slowing and easing its progression
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Parkinson's disease instantly changes the lives of those diagnosed with it
and while no one knows the cause, doctors at the Nebraska Medical Center are
working on a way to possibly ease the pain and some of the effects.
Med center researchers are fine-tuning a vaccine they thought would be the
answer to the prayers of those taking medication to stop the progression of
Parkinson's. Here's why they may have to start over.
Conversation is easy for 52-year-old Monnie Lindsay, but at 38, she says
doctors gave her troubling news. "It's a horrible disease. It continues to
progress. For those that have advanced disease, it's like living life in a
locked box."
Researchers are working on relief for Lindsay and the one-and-a-half million
Parkinson's patients across the country. "We want to prevent the natural
events of the immune system attacking the brain and speeding the disease
process," says the Nebraska Medical Center's Dr. Howard Gendelman.
To do that, researchers had been working on a vaccine, testing it on lab
mice, but the vaccine didn't work as planned. It didn't slow or stop the
disease. In fact, the vaccine produced results in the mice similar to
advanced-stage Parkinson's in humans.
Now, researchers are re-examining the vaccine and how proteins and our
immune system contribute to the disease. "It's not a cure, it's not a
prevention of Parkinson's disease, it's an alleviation of the disease itself
or the course of the disease," says Dr. Gendelman.
Until then, those living with Parkinson's, like Lindsay, will have to
continue taking their prescribed medication. For some Parkinson's patients,
medications aren't even enough to treat the disease. In extreme situations
they often undergo surgery.
What's next for the research at the med center? Doctors would of course like
to get the vaccine to Parkinson's patients as soon as possible. However,
getting a vaccine approved is a lengthy process. There's no set timetable as
to when the vaccine will be available.

Rayilyn Brown
Board Member AZNPF
Arizona Chapter National Parkinson's Foundation
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