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What does this all mean? i'm specially interested in this one. can someone translate this into simpler language, conclusion or recommendation? Thanks Much ----- Original Message ----- From: "M.Schild" <[log in to unmask]> To: <[log in to unmask]> Sent: Saturday, February 16, 2008 5:12 PM Subject: ldopa > Striatal Proteomic Analysis Suggests that First L-Dopa Dose Equates to > Chronic > Exposure > > L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a > debilitating complication of therapy for Parkinson's disease (PD) that > result > from a progressive sensitization through repeated L-dopa exposures. The > MPTP > macaque model was used to study the proteome in dopamine-depleted striatum > with and without subsequent acute and chronic L-dopa treatment using > two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass > spectrometry. The present data suggest that the dopamine-depleted striatum > is > so sensitive to de novo L-dopa treatment that the first ever > administration > alone would be able (i) to induce rapid post-translational > modification-based > proteomic changes that are specific to this first exposure and (ii), > possibly, lead to irreversible protein level changes that would be not > further modified by chronic L-dopa treatment. The apparent equivalence > between first and chronic L-dopa administration suggests that priming > would > be the direct consequence of dopamine loss, the first L-dopa > administrations > only exacerbating the sensitization process but not inducing it. > > the whole article on: > http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001589;jsessionid=6BD6E5B19ADF03980A5560E96564AC00 > > maryse > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn