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> What does this all mean? i'm specially interested in this one. can someone > translate this into simpler language, conclusion or recommendation? means that so far they thought secondary effects of ldopa were the consequence of long term exposition to ldopa. This study on macaques shows the first time one uses ldopa there is an irerreversible change in the striatum that may well be the first step to secondary effects. conclusion is it is time to find something that lessens those secondary effects-serotonin could be an answer maryse ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn