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This was certainly the case with my husband. Some years previous to his diagnosis of PD, we were surprised to find that he was gradually losing his sense of smell. We put it down to the fact that he had been a smoker in his younger days. I found out about the link between PD and a loss of the sense of smell when I was searching the net for symptoms of PD before we actually went to the doctor. He had all the initial symptoms including a loss of the sense of smell. Moneesha Sharma On Sat, Mar 22, 2008 at 6:58 AM, rayilynlee <[log in to unmask]> wrote: > Your nose may warn about onset of Parkinson's > > From correspondents in Washington, United States, 11:31 AM IST > > An impaired sense of smell occurs in the earliest stages of Parkinson's > disease (PD) and there is mounting evidence that it may precede motor > symptoms by several years, according to a study. > The study, by researchers at the Pacific Health Research Institute in > Hawaii, found that smell impairment can precede the development of PD in > men > by at least four years. > Findings of the study have been published in the latest edition of the > Annals of Neurology, the official journal of the American Neurological > Association. > Led by G. Webster Ross of the VA Pacific Islands Health Care System and > the > Pacific Health Research Institute in Honolulu, Hawaii, the study included > 2,267 men who received an olfactory test and were followed for up to eight > years to find out if they developed PD. During the course of follow-up, 35 > men developed the disease. > The results showed that a smell identification deficit could predate the > development of PD by at least four years, although it was not a strong > predictor beyond this time period. > A decreased ability to identify odours was associated with older age, > smoking, more coffee consumption, less frequent bowel movements, lower > cognitive function and excessive daytime sleepiness, but even after > adjusting for these factors, those with poor odour identification had a > five > times greater risk of developing PD. > The pathology of smell impairment in PD is not completely understood, but > nerve loss and the formation of Lewy bodies, abnormal clumps of proteins > inside nerves cells that are thought to be a marker of PD, are known to > take > place in the olfactory structures of patients with the disease. > The authors note that one study involving brain dissection of dead > patients > with neurological disease found that olfactory structures are the earliest > brain regions affected by Lewy degeneration, which supports the idea that > an > impaired sense of smell could be one of the earliest signs of the disease. > (Staff Writer, (c) IANS) > > Rayilyn Brown > Board Member AZNPF > Arizona Chapter National Parkinson's Foundation > [log in to unmask] > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn