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From a layman's point of view, there is no etiological connection but there is a link. It is my theory that many of our symptoms are slowly exacerbated by our breathing problems. PD affects all muscle systems and many other of our bodies workings. Breathing can be affected by rigidity and other pd effects and I notice after a bad night for sleep I almost have to remind myself to breath. Fortunately we can consciously affect our breathing thru various exercises and devices. At night it is helpful to wear a nose strip or use a Nozovent which find indispensable. I think that capd would have a positive effect. Have fun! \Randy Games To Entertain Your Brain http://www.stargraphics.com ----- Original Message ----- From: "Peggy Willocks" <[log in to unmask]> To: <[log in to unmask]> Sent: Sunday, March 23, 2008 11:39 AM Subject: Sleep apnea and PD? >I have always wondered about whether or not sleep apnea had any bearing on > getting Parkinson's or advancing progression at a faster rate. And would > using a CPAP machine (breathing machine) make any difference? I have used > a > CPAP machine for about 5 years > > How many of you have sleep apnea? > Peggy > > I read an article recently about misfolded proteins in sleep apnea. > Although a bit technical, here is an excerpt: > > (quote) In a mouse model of sleep apnea, the researchers found that motor > neurons of the jaw and face had swollen endoplasmic reticula, the part of > the cell where proteins get folded properly. They surmised that misfolded > proteins accumulated as the endoplasmic reticula of mice were exposed to > decreased oxygen and oxygen fluctuations during sleep over eight weeks. > The > involvement of the endoplasmic reticula has never been shown before in > explaining the physiology of sleep apnea on a cellular level . . . Sensor > proteins sitting on the surface of the endoplasmic reticula get activated > by > poorly folded proteins within. The Penn group worked with one of those > proteins, called PERK. When PERK gets activated, two things can happen: > The > cell can take a pathway to fix itself or one that leads to self > destruction. > The cell makes that decision based on its initial health.(end quote) > > source: Univ. of Pennsylvia School of Medicine > Medical News > http://www.news-medical.net/?id=36503 > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn