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I feel lucky I was helped by DBS. I feel like mentally I am sharper, no more ocular migraines, am never depressed , no more shaking, speaking is a real problem though. My other PD symptoms seem to have plateaued - no meds. Ray Rayilyn Brown Board Member AZNPF Arizona Chapter National Parkinson's Foundation [log in to unmask] ----- Original Message ----- From: "M.Schild" <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, March 28, 2008 12:23 PM Subject: DBS Adverse Events: Results from 1154 PD Patients > Deep brain stimulation for Parkinson's disease: Prevalence of adverse > events > and need for standardized reporting > A Videnovic, L Verhagen Metman > Movement Disorders 2008;23:343-349 > > > Adverse events related to deep brain stimulation are common, but their > true > prevalence cannot be accurately determined with current reporting methods, > according to this study. > > The authors analyzed reports of adverse events from 47 studies of STN and > GPi > DBS in PD published from 1996 to 2007, representing 1,154 patients (928 > STN, > 226 GPi) and 2,205 electrode placements. They grouped AEs into three > classes: > procedure-related, hardware-related, and stimulation- or disease > progression-related events. > > The most common events were: > > Procedure-related events: > STN (%) GPi (%) > Mental status/behavioral 18.4 9.3 > Infection 2 2.6 > ICH-symptomatic 2 4 > Misplaced electrode 1.7 2 > Speech disturbance 1.5 3.9 > Infarction 0.2 2.2 > > Among mental status changes, confusion was by far the most common. > > Hardware-related events (combined GPi and STN, %): > Infection 2.4 > Malfunctioning 1 > Lack of benefit 0.9 > > A total of 8.7% of patients experienced one or more hardware-related AE. > > Stimulation- or progression-related events, which did not disappear with > adjustment (%): > STN (%) GPi (%) > Weight gain 37.5 17.6 > Dysarthria 12.8 11.8 > Eyelid opening apraxia 11.3 0 > Gait ignition failure 0 17.6 > > Because of the variation in classification of AE reporting among the > included > studies, the authors note that "a retrospective review of the available > literature cannot provide accurate data on the prevalence of AEs > associated > with DBS in PD." They recommend the adoption of a standardized system for > AE > reporting in DBS trials, in which all AEs are classified along the lines > they > employed in this study, plus the temporal characteristics of the AE and > its > response to programming adjustments. > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn