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Pathologic Gambling. Case Reports Cognitive & Behavioral Neurology. 20(1):11-14, March 2007. Garcia, Rafael Ferreira BS *; Ordacgi, Lidia BS *; Mendlowicz, Mauro V. MD, PhD +; de Freitas, Gabriel R. MD, PhD ++; Rosso, Ana Lucia Z. MD, PhD ++; Nazar, Bruno P. MD, PhD *; Fontenelle, Leonardo F. MD, PhD * + Abstract: Objective: To describe the recurrent emergence of pathologic gambling (PG) during the sequential treatment of a patient with Juvenile Parkinson disease (PD) with different dopamine agonists. Method: Single case report. Results: A patient with Juvenile PD developed PG soon after beginning treatment with pergolide, a mixed D1/D2 dopamine agonist that is also supposed to exhibit D3 activity. This behavior remitted upon the discontinuation of the drug. A subsequent therapeutic trial with pramipexole, a dopamine agonist with preferential D3 dopamine receptor activity, resulted in the recurrence of PG. Remarkably, previous treatment with levodopa was not associated with this side effect. Conclusions: These findings seem to confirm previous suggestions that dopaminergic hyperactivity plays an important role in the pathogenesis of PG. They further indicate that patients with PD may develop PG as a side effect of more than one dopamine agonist. There is still no consensus regarding the best strategy to deal with this potentially disturbing phenomenon. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn