 |
 |
Tumeric considered an antiseptic, is used in very small quantities in cooking curry primarly for colour/tradition wonder what quantities are being talked about would be interested in details. Haroon Basheer Chairman Pakistan Parkinson's Society www.parkinsons.org.pk karachi 2008/6/15 rockiepark <[log in to unmask]>: > On May 28, 2008, at 8:24:42 AM, "Moneesha Sharma" < > [log in to unmask]> wrote: > From: "Moneesha Sharma" > Subject: Re: Turmeric for Parkinson's > Date: May 28, 2008 8:24:42 AM EDT > To: [log in to unmask] > Amazing! We use turmeric almost every day in our cooking but probably not > in the kinds of quantities that would make a difference. > > NIMHANS in Bangalore is a very reputed institution. > > Moneesha > Wife of Prem 62/56/54? Calcutta, India > > > > On Wed, May 28, 2008 at 2:51 PM, M.Schild <[log in to unmask]> wrote: > > > Turmeric for Parkinson's > > > > Subhra Priyadarshini > > The researchers: Mythri, Bharath, JagathaThe researchers: Mythri, > Bharath, > > Jagatha > > > > Curcumin, the wonder compound in turmeric, has found another possible > > therapeutic use — this time for treatment of Parkinson's Disease1. > > > > Researchers conducting experiments on mice have shown that curcumin > > increased > > the content of glutathione (GSH), an anti-oxidant in certain nerve cells > of > > the brain that control body movement. The increased GSH protects the > brain > > against abnormal accumulation of toxic free radicals that damage the > > mitochondria of these nerve cells triggering off Parkinson's Disease > (PD). > > > > "During Parkinson's, there is a gradual death of specific nerve cells > > called > > dopaminergic neurons in the mid-brain. If we understand why these cells > > die, > > we can slow the process down or reverse it by developing better > therapies," > > says M. M. Srinivas Bharath, the lead researcher. > > > > During early PD, there is a significant depletion of GSH leading to > > abnormal > > accumulation of toxic free radicals. These free radicals damage > > mitochondria, > > the powerhouse of the cell, ultimately killing the nerve cells. "So, if > we > > could prevent depletion of GSH in mid-brain nerve cells, we could protect > > nerve cells against degeneration," Bharath says. > > > > The team found that selective GSH depletion in mid-brain nerve cells > > damaged > > mitochondria mimicking an early PD condition. To protect against this > > insult, > > they administered curcumin. The compound protected mouse brain and nerve > > cells in culture by increasing the GSH content and protecting against > toxic > > free radicals thus exhibiting therapeutic potential in early PD. > > > > To support this conclusion, the team used computer simulations and > > biochemical > > experiments. They simulated disease pathways of PD using mathematics and > > computer modeling to generate a virtual experimental system that gives a > > complete picture of disease cascades and potential therapeutic targets. > > Using > > this 'in silico' model, they corroborated that curcumin could be a > > potential > > therapeutic compound in PD. > > > > The authors of this work are from: Department of Neurochemistry, National > > Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, > > Karnataka, India; Cell works group Inc., Marathahalli, Bangalore & Pierce > > Road, Saratoga, CA, USA. > > > > * > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: mailto: > > [log in to unmask] > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto: > [log in to unmask] > In the body of the message put: signoff parkinsn >