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June 25, 2008 - New Research DYSKINESIA IS RELATED TO WEIGHT European Journal of Neurology [2008] 15 (5) : 493-496 (Sharma JC, Ross IN, Rascol O, Brooks D.) Complete abstract L-dopa dose per kilogram body weight is reported to be a significant factor for dyskinesia in Parkinson's disease. This study investigated this hypothesis. Analysis of L-dopa therapy patients revealed that people with dyskinesia had received significantly higher L-dopa dose, and also had a higher L-dopa dose per kilogram body weight. The most significant factor was the higher L-dopa dose per kilogram body weight. Younger age was the factor that was the second most related to dyskinesia. Gender, absolute L-dopa dose, weight on its own, disease duration, and initial motor Unified Parkinson's disease rating score were not significant. Higher L-dopa dose per kilogram body weight is an independently significant factor for developing dyskinesia. This relationship should be considered as an important factor in the treatment of Parkinson's Disease when aiming to prevent and manage dyskinesia, because those of a lower weight will be far more prone to dyskinesia. Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn