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E-MOVE reports from the 12th International Congress of Parkinson's Disease and Movement Disorders, sponsored by the Movement Disorders Society and held in Chicago June 22-26, 2008. Abstract numbers and pages refer to abstracts published in Movement Disorders 2008;23(suppl 1). Deep brain stimulation is superior to best medical therapy for Parkinson's disease for at least 6 months, although the risk of adverse events from surgery is much higher, according to this randomized trial. Two hundred fifty-five patients were randomized to best medical therapy (BMT) or DBS of the STN or GPi (also chosen randomly). Patients had a mean age of 63, were a mean of 12 years post-diagnosis, and were 80% male. Assessments included patient diaries, blinded UPDRS motor ratings, and quality of life with the PDQ-39. At six months, patients receiving DBS had 5.1 hours increased on time, versus no change with BMT. Off-medication motor function was 36% improved with DBS, versus 4% with BMT. DBS patients had significantly better quality of life compared to BMT for all aspects of the PDQ-39 except social support. Serious adverse events occurred in 49 DBS patients, and 15 BMT patients, making the incidence risk ratio 3.8 for DBS vs. BMT. Funding was provided by US government agencies and by Medtronic. Best medical therapy vs. deep brain stimulation for PD: Six month result from a multi-site randomized trial FM Weaver, VA CSP #468/NINDS Study Group 597;S197 ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn