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16th July 2008 - New research
suicide in parkinson's disease
Movement Disorders [2008] Jul 10; [Epub ahead of print] (Nazem S, Siderowf 
AD, Duda JE, Brown GK, Ten Have T, Stern MB, Weintraub D.) Complete abstract

In Parkinson's disease, there is a high prevalence of depression. This is 
because dopamine, whose deficiency normally causes the muscular symptoms of 
Parkinson's Disease, also affects the emotions. Many people with Parkinson's 
Disease consequently effectively become biochemically depressed. Depression 
increases the likelihood of suicide and thoughts of death. However, little 
was known of their prevalence in Parkinson's Disease. People with 
Parkinson's Disease were assessed using the Paykel scale.  Respondents 
answer each item either "yes" or "no" to the following questions. The items 
can assess suicidality during the past week, month, year or lifetime. More 
relevant to somebody with Parkinson's Disease is for the answers to concern 
recent months :
1. Have you ever felt that life was not worth living ?
2. Have you ever wished you were dead? for instance, that you could go to 
sleep and not wake up ?
3. Have you ever thought of taking your life, even if you would not really 
do it ?
4. Have you ever reached the point where you seriously considered taking 
your life or perhaps made plans how you would go about doing it?
5. Have you ever made an attempt to take your life ?
Extensive psychiatric, neuropsychological, and neurological assessments were 
also carried out. Thoughts of death occurred in 28% of patients. Thoughts of 
suicide occurred in 11% of patients. Thoughts of either had occurred in 30% 
of patients. Of all those assessed, 4% had attempted suicide during their 
lifetime. Depression was far more common than normal. Even more common was 
impulse control disorder, but this was probably due to Parkinson's Disease 
drugs, especially dopamine agonists. Psychosis was also far more common in 
Parkinson's Disease, but this was also probably due to Parkinson's Disease 
drugs, especially L-dopa.

source: Viartis

Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
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