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Proof-of-concept for diagnosing Parkinson's disease using non-invasive, 
biospectrosco

Molecular Biometrics Announces Results of Parkinson's Disease Research and 
Receipt of Grant From Michael J. Fox Foundation to Advance Diagnostic 
Technology

Tuesday August 5, 10:44 am ET

http://biz.yahoo.com/prnews/080805/netu081.html?.v=60

New research demonstrates proof-of-concept for diagnosing Parkinson's 
disease using non-invasive, biospectroscopy technology

Michael J. Fox Foundation awards grant to Molecular Biometrics for further 
development of Parkinson's diagnostic CHESTER, N.J. and MONTREAL, Aug. 5 
/PRNewswire/ -- A study published in the June issue of the peer-reviewed 
journal, Biomarkers in Medicine, demonstrated proof-of-concept for the use 
of a minimally-invasive technology being developed by Molecular Biometrics, 
LLC, to diagnose Parkinson's disease (PD). In the study, researchers used 
spectroscopy to develop a metabolic profile (or chemical signatures) of 
biological markers for PD. There is currently no definitive laboratory 
diagnostic for Parkinson's disease.

The company also announced receipt of an award from The Michael J. Fox 
Foundation for Parkinson's Research supporting further development of its 
technology platform to validate its PD diagnostic methodology.

"The lack of an objective biomarker to aid diagnosis and therapeutics 
development is one of the single greatest challenges facing the Parkinson's 
research field," said Katie Hood, CEO of The Michael J. Fox Foundation. "We 
are enthusiastic about helping to keep Molecular Biometrics' novel 
metabolomic diagnostic technology moving forward toward validation and 
clinical testing."

Researchers at Molecular Biometrics, Lady Davis Institute (LDI), Sir 
Mortimer B. Davis - Jewish General Hospital and McGill University have shown 
that, using biospectroscopy methods to create a specific biomarker profile, 
they can distinguish idiopathic Parkinson's disease from normal aging and 
other neurodegenerative conditions. Diagnosis of PD is currently based 
solely on a patient's medical history and neurological examination, making 
Parkinson's difficult to diagnose, particularly during early stages of the 
disease.

"We created a biomarker profile, using biospectroscopy techniques, to 
delineate a chemical signature in blood that identifies patients with 
Parkinson's disease," said Hyman M. Schipper, MD, PhD, FRCPC, lead author of 
the study and member of the Faculty of Medicine, Department of Neurology and 
Neurosurgery, and Department of Medicine, McGill University, and member of 
the Attending Staff in Neurology at Sir Mortimer B. Davis - Jewish General 
Hospital, in Montreal, Canada. "This proof-of-concept gives us great hope 
that biospectroscopy will offer a new approach to the early diagnosis of 
Parkinson's disease and other neurodegenerative disorders." Dr Schipper is a 
noted expert in brain aging and neurodegeneration, and a Founding Scientist 
and Medical Director (Neurosciences) at Molecular Biometrics.

In the study, fifty-two patients, 20 with mild or moderate stages of 
Parkinson's disease and 32 age-matched control subjects were recruited at 
the Jewish General Hospital. Whole blood samples were analyzed using near- 
infrared (NIR) spectroscopy and Raman spectroscopy (RS) methods which have 
previously been used to create metabolomic profiles (chemical signatures) of 
human biofluids, including serum and whole blood.

Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
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