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N-Methyl or Dimethylamine is elevated in Parkinson's disease. 
Micro-organisms give off N-Methyl. Thought it was part of the problem. It 
can attach to tellurium to become Dimethyltelluride. Blue tends to involve 
copper-sulfur proteins or enzymes. Alpha-synuclein has a copper center. 
Cytochrome C of complex IV aggregrates alpha synuclein into Lewy bodies. 
Cytochrome C is a copper enzyme. If it caused brain damage at high doses, 
would think it would cause brain damage at low doses. But it does point to 
blue, and copper, and something that can bind with copper, like the 
semi-metal, in the sulfur family, tellurium that can result in 2 positively 
charged copper ions binding with 2 negatively charged tellurium ions. Think 
the organisms cannot recognize the difference between blue copper proteins 
and non-blue copper proteins. Thanks for the info. Will have to write to 
these guys.
Sharon

----- Original Message ----- 
From: "rayilynlee" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Monday, August 18, 2008 10:21 PM
Subject: Century-old drug a PD Cure?


> Scientists: century-old drug might cure Parkinson's, more
> Aug. 18, 2008
> Courtesy Chil­dren's Hos­pi­tal &
> Re­search Cen­ter Oak­land
> and World Science staff
> A study with mice sug­gests a century-old drug, meth­yl­ene blue, could 
> slow or even cure Alz­heim­er's and Park­in­son's dis­ease in small doses, 
> re­search­ers say.
>
> "To find that such a com­mon and in­ex­pen­sive drug can be used to 
> in­crease and pro­long the qual­ity of life by treat­ing such se­ri­ous 
> dis­eases is truly ex­cit­ing," said Bruce Ames, a co-author of the study 
> at Chil­dren's Hos­pi­tal & Re­search Cen­ter Oak­land, in Cal­i­for­nia.
>
> Mi­to­chon­dria are small com­part­ments par­ti­tioned by mem­branes and 
> found in com­plex cells. These or­ganelles are of­ten called the "power 
> plants" of the cell be­cause their main job is to make en­er­gy. Above, a 
> a mi­to­chon­d­rion shown in an ar­tist's de­pic­tion for clar­ity. 
> (Im­age cour­te­sy US Nat'l Sci­ence Founda­tion)
>
> Led by Hani Atamna at the center, re­search­ers stud­ied the drug's 
> ef­fects on lab­ora­tory-cultured cells and mice.
>
> In very low con­centra­t­ion­s-the equiv­a­lent of a few rain­drops in 
> four Olym­pic-sized swim­ming pools-the drug slows cel­lu­lar ag­ing and 
> en­hances the func­tion of cel­lu­lar "power plants" called 
> mi­to­chon­dria, the ex­pe­ri­menters said.
>
> Their re­sults ap­peared in the March is­sue of the Fed­er­a­t­ion of 
> Amer­i­can So­ci­eties for Ex­pe­ri­men­tal Bi­ol­o­gy Jour­nal.
>
> The group found meth­yl­ene blue could pre­vent or slow mi­to­chon­drial 
> de­cline, spe­cif­ic­ally that of an im­por­tant en­zyme called com­plex 
> IV. Mi­to­chon­dria are the main en­er­gy sup­pli­ers to an­i­mal and 
> hu­man cells.
>
> "The re­sults are very encourag­ing," said Atam­na. "One of the key 
> as­pects of Alz­heim­er's dis­ease is mi­to­chon­drial dys­func­tion, 
> spe­cif­ic­ally com­plex IV dys­func­tion," he went on. Meth­yl­ene blue 
> seems to ex­pand the brain's "mi­to­chon­drial re­serve," he added, 
> "essen­tial for pre­vent­ing age-related dis­or­ders."
>
> Dis­cov­ered in 1891, meth­yl­ene blue is used to treat 
> me­the­mo­glo­bine­mia, a blood dis­or­der. But be­cause high 
> con­centra­t­ions of meth­yl­ene blue were known to dam­age the brain, no 
> one thought to ex­pe­ri­ment with low con­centra­t­ions, Atam­na's group 
> said. Al­so, drugs such as meth­yl­ene blue don't easily reach the brain.
>
> Atamna said meth­yl­ene blue could be­come an­oth­er com­monplace low-cost 
> treat­ment like as­pi­rin, pre­scribed as a blood thin­ner for peo­ple 
> with heart dis­or­ders.
>
> Rayilyn Brown
> Director AZNPF
> Arizona Chapter National Parkinson Foundation
> [log in to unmask]
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