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David, The FDA-approved prescribing information mentions that laboratory tests often show reduced blood levels of uric acid associated with Sinemet (I assume that is what you are taking, since levodopa is rarely prescribed by itself). Gout is often considered to be caused by elevated levels of blood uric acid. There is no specific mention of gout in the prescribing information. Having said this, I heard a presentation at the American Academy of Neurology last April about the association of increased blood urate with slower progression of PD. The Fox Foundation has made a major grant supporting the study of inosine (a dietary supplement that increases blood uric acid levels) and the progression of PD. It's not clear what the relationship between gout/uric acid and PD is yet, but you might want to ask you doc to check your uric acid level. Wilson In a message dated 8/25/2008 2:00:18 A.M. Eastern Daylight Time, [log in to unmask] writes: I was wondering if any of the PD members on the list have the experience of having gout. Recently I developed the classical tenderness and swelling in my big toe. In researching this disease on the net, I discovered to my surprise that gout can occur as a side-effect of taking levodopa. Since I have been taking this drug every day for five years under 4 different doctors supervision, I feel a little put out that I had to develop the symptom to learn about the side-effect. Yours truly, David **************It's only a deal if it's where you want to go. Find your travel deal here. (http://information.travel.aol.com/deals?ncid=aoltrv00050000000047) ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn