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Zonisamide This page contains recent news articles, when available, and an overview of Zonisamide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns. Overview: Zonisamide (when available) Pharmacology and use: Zonisamide is used primarily as an anticonvulsant for the adjunctive treatment of epilepsy. The precise mechanism by which Zonisamide exerts its antiseizure effect is unknown, although it is believed that the drug blocks sodium channels which leads to the suppression of neuronal hypersynchronization (i.e. convulsions). Likewise Zonisamide has also been found not to potentiate syanptic activity by GABA (gamma amino butyric acid). Adjunctive treatment of partial seizures in adults with epilepsy. Mechanism Of Action: Zonisamide binds to sodium channels, voltage sensitive calcium channels and to a lesser extent carbonic anhydrase. This blocks or suppresses neuronal depolarization and hypersynchronization. Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn