Source: Viartis
PARKINSON'S DISEASE NEWS
16th September 2008 - New
review
FUNGICIDE
AS A CAUSE OF PARKINSON'S DISEASE
Maneb is a fungicide that contains manganese. The major active element of
Maneb is manganese ethylene-bis-dithiocarbamate. Pesticides are known to be
associated with an increased rate of Parkinson's Disease [3].
Common means : Maneb is used as a fungicide. There is a greatly increased
likelihood of developing symptoms by people involved in horticulture and
agriculture [2].
Means of toxicity : As Maneb contains manganese it is possible that it
causes Parkinson's Disease symptoms via the same means as manganese, which
is by inhibiting tyrosine hydroxylation, which is essential for the
formation of dopamine. It would thereby lower dopamine levels. The effects
of Maneb are potentiated when there is simultaneous exposure to the
pesticide Paraquat [4-8].
Symptoms of toxicity : Plastic rigidity with cogwheel phenomenon, headache,
fatigue, nervousness, memory complaints, and sleepiness, other neurologic
signs, such as postural tremor, cerebellar signs, and bradykinesia [1];
damaging effects on the dopaminergic system [4-8], that it can, quite
unusually, even affect prior to birth [4-8]. This suggests that somebody
could be affected by fungicide because of their Mothers exposure to it
during their pregnancy.
References : [1] Neurology [1988] 38 (4) : 550-553 (H.B.Ferraz,
P.H.Bertolucci, J.S.Pereira, J.G.Lima, L.A.Andrade), [2] Scandinavian
journal of work, environment & health. [2000] 26 (4) : 359-362 (F.Tuchsen,
A.A.Jensen), [3] Neurology [1998] 50 (5) : 1346-1350 (J.M.Gorell,
C.C.Johnson, B.A.Rybicki, E.L.Peterson, R.J.Richardson), [4] Birth defects
research. Part A, Clinical and molecular teratology [2005] 73 (3) : 136-139
(D.A.Cory-Slechta, M.Thiruchelvam, E.K.Richfield, B.K.Barlow, A.I.Brooks),
[5] Developmental neuroscience [2004] 26 (1) : 11-23 (B.K.Barlow,
E.K.Richfield, D.A.Cory-Slechta, M.Thiruchelvam), [6] The European journal
of neuroscience [2003] 18 (3) : 589-600 (M.Thiruchelvam, A.McCormack,
E.K.Richfield, R.B.Baggs, A.W.Tank, D.A.Di Monte, D.A.Cory-Slechta), [7]
Neurotoxicology [2002] 23 (4-5) : 621-633 (M.Thiruchelvam, E.K.Richfield,
B.M.Goodman, R.B.Baggs, D.A.Cory-Slechta), [8] The Journal of neuroscience
[2000] 20 (24) : 9207-9214 (M.Thiruchelvam, E.K.Richfield, R.B.Baggs,
A.W.Tank, D.A.Cory-Slechta)
Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
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