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Thursday, September 25, 2008 What are your chances of inheriting PD If any member of your family has a history of PD, it is highly probable that you might be predisposed to the disease. The gene which has created a buzz in the scientific community for its role in PD is LRRK2. It is a relatively new gene and lots of scientific research is being carried out now and information is pouring in at a constant pace. The mutation which has been prominent is the G2019S mutation on the LRRK2 gene found in chromosome 12. The single-letter change in the DNA code dramatically increases a person's odds of developing Parkinson's from one or two in a hundred to as much as eight in 10. One recent study found that a person who inherits the mutation has a 28% chance of developing Parkinson's by the age of 59, 51% by the age of 69 and 74% by the age of 79 (Healy et al. 2008, Lancet, 7, 583-590). Posted by Saurabh Sen at 10:29 AM Rayilyn Brown Director AZNPF Arizona Chapter National Parkinson Foundation [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn