This is interesting to me, but I do wonder what is the chance of inhereting the mutated gene if there is a family history of PD. This article points out what your chance is for developing PD if you inherit the gene, but what is the chance of inheriting the gene? Does anyone know? Both my mom (at age 70) and I (at age 47) became symptomatic, so I wonder how that bodes for my siblings and my offspring...Kristin
----- Original Message ----
From: rayilynlee <[log in to unmask]>
To: [log in to unmask]
Sent: Friday, September 26, 2008 9:22:33 PM
Subject: Inheriting PD
Thursday, September 25, 2008
What are your chances of inheriting PD
If any member of your family has a history of PD, it is highly probable that
you might be predisposed to the disease. The gene which has created a buzz
in the scientific community for its role in PD is LRRK2. It is a relatively
new gene and lots of scientific research is being carried out now and
information is pouring in at a constant pace.
The mutation which has been prominent is the G2019S mutation on the LRRK2
gene found in chromosome 12. The single-letter change in the DNA code
dramatically increases a person's odds of developing Parkinson's from one or
two in a hundred to as much as eight in 10. One recent study found that a
person who inherits the mutation has a 28% chance of developing Parkinson's
by the age of 59, 51% by the age of 69 and 74% by the age of 79 (Healy et
al. 2008, Lancet, 7, 583-590).
Posted by Saurabh Sen at 10:29 AM
Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
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