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New Research Uses Male Testicle Cells to Create Stem Cells
   By Jessica Berman 
 Washington
 09 October 2008
 

 
Scientists have created stem cells from human male testicle cells. Experts say 
the development may provide one more alternative to the controversial use of 
human embryonic stem cells to grow replacement tissue. VOA's Jessica Berman 
reports. 

Stem cells are known as "pluripotent cells", meaning they can be manipulated 
to grow into any cell in the body, potentially offering replacement tissue 
for a range of illnesses, including Parkinson's disease, diabetes and spinal 
cord injury. 

Human embryos are a rich source of stem cells, but the use of growing embryos 
is prohibited in the US and other countries, including Germany, because 
extracting the master cells destroys them.

So, researchers have been searching for alternative sources to embryonic stem 
cells that are just as versatile but without the controversy.

October 2008 edition of 'Nature' scientific journal  October 2008 edition 
of 'Nature' scientific journal
  In a paper published this week in the journal Nature, German researchers 
report on the latest effort. By reprogramming the testicle cells of 22 males 
between the ages of 17 - 81, researchers are coaxing them to begin the 
process of becoming muscle, bone and nerve cells. 

Thomas Skutella, a professor at the Center for Regenerative Biology and 
Medicine in Tuebingen, Germany, is the study's lead author. 

Skutella says the extraction and manipulation of stem cells from germ cells 
which produce sperm, had previously been achieved in mice, prompting 
investigators to try the same experiments in humans.

"We were looking for pluripotent cells of different origin [than human 
embryonic stem cells]. And there were hints that those cells might be found 
in the germ cells which make sperm. And it has been shown those cells might 
be pluripotent, so that was a starting point," Skutellla explained.

Unfortunately, experts say women would not benefit from the latest stem cell 
development. But Skutella says a similar technique may be used to grow stem 
cells for women from egg cells. 

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