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OK - so someone give the gene a good kick to get it started ? Quoting rayilynlee <[log in to unmask]>: > PARKINSON'S DISEASE NEWS > > 26th November 2008 - New research Source: Viartis > THE ROLE OF THE PARKIN GENE IN WORSENING PARKINSON'S DISEASE > Journal of Cell Biology [2008] Nov 24. [Epub ahead of print] (Narendra D, > Tanaka A, Suen DF, Youle RJ.) Complete abstract > The primary fault in Parkinson's Disease is the insufficient formation of > dopamine. When dopamine fails to form properly the highly damaging > superoxide anion is formed instead. For more information go to the > Biochemistry of Parkinson's Disease under Cell Damage. This can cause > further deterioration in Parkinson's Disease. Although cell damage is widely > > claimed to cause Parkinson's Disease, it is more accurate to say that > Parkinson's Disease can cause cell damage that can worsen already existing > Parkinson's Disease. Cell damage perpetuates far more when there is a > genetic lack of the Parkin gene. Those people with this genetic disorder are > > consequently known to be more susceptible to developing Parkinson's Disease > than any of the various genetic causes of Parkinson's Disease. It makes > Parkinson's Disease more likely rather than inevitable. Parkin is known to > help rid damaged elements in the cells involved in Parkinson's Disease. > Although the role of Parkin in cell maintenance was unknown, recent work has > > linked Parkin to the regulation of mitochondria. The mitochondria is the > energy producing part of cells. New research has shown that the Parkin gene > is selectively involved in getting rid of dysfunctional mitochondria after > it has been damaged due to Parkinson's Disease. Parkin mediates the > engulfment of mitochondria, and then its elimination. When this fails to > occur, as it does in the Parkin form of genetic Parkinson's Disease, damaged > > elements within the nerve cells accumulate and cause the functioning of > those nerve cells to deteriorate even further. > > Rayilyn Brown > Director AZNPF > Arizona Chapter National Parkinson Foundation > [log in to unmask] > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------- This mail sent through http://www.ukonline.net ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn